Regulatory Status
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Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for 2,6-Diaminopyridine ⚠️ based on clinical patch test studies and IFRA standards.
Source: SCCS; IVDK
Expert Verdict
Extreme sensitizer with mutagenic and clastogenic potential in vitro; high acute oral toxicity (LD50 50–300 mg/kg bw); nephrotoxicity and hemolytic anemia observed at ≥10 mg/kg in 90-day studies with target organs including kidney, erythrocytes, liver, and spleen.
Regulatory Flags
Frequently Asked Questions
Is 2,6-Diaminopyridine ⚠️ safe in cosmetics?
Extreme sensitizer with mutagenic and clastogenic potential in vitro; high acute oral toxicity (LD50 50–300 mg/kg bw); nephrotoxicity and hemolytic anemia observed at ≥10 mg/kg in 90-day studies with target organs including kidney, erythrocytes, liver, and spleen. The EU classifies 2,6-Diaminopyridine ⚠️ as "prohibited". Safety rating: POOR.
Is 2,6-Diaminopyridine ⚠️ allowed in the EU?
2,6-Diaminopyridine ⚠️ EU regulatory status: prohibited. Maximum allowed concentration: 0.3%. This is based on EU Regulation 1223/2009 and its amendments.
What does 2,6-Diaminopyridine ⚠️ do in cosmetics?
2,6-Diaminopyridine ⚠️ functions as: Hair dyeing (oxidative hair dye precursor, max 0.15% after mixing). It is classified as a cosmetic ingredient in our database. CAS number: 141-86-6.
What is the Margin of Safety for 2,6-Diaminopyridine ⚠️?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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