Is 2,6-Diaminopyridine ⚠️ safe in cosmetics?
2,6-Diaminopyridine ⚠️ has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted.
2,6-Diaminopyridine ⚠️
Also known as: 5-22-11-00255, BRN 0108513, EINECS 205-507-2, UNII-K89AB8CKG6
INCI: 2,6-DIAMINOPYRIDINE
2,6-Diaminopyridine ⚠️ (CAS 141-86-6) is a cosmetic cosmetic ingredient functioning as Hair dyeing (oxidative hair dye precursor, max 0.15% after mixing). EU Regulation 1223/2009 status: prohibited, max 0.3%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 141-86-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2,6-Diaminopyridine ⚠️ is prohibited in EU cosmetics at max 0.3% but has active industrial GHS classifications (H301, H315, H317, H319, H335, H411).
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair dyeing (oxidative hair dye precursor, max 0.15% after mixing)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
pyridine-2,6-diamine
InChIKey
VHNQIURBCCNWDN-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
EU Max Conc.
0.3%
US US Status
permitted
US Notes
Permitted under coal tar hair dye exemption
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2,6-Diaminopyridine ⚠️.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for 2,6-Diaminopyridine ⚠️ based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
dye
EU Allergen Listed
no
Patch Test Positive Rate
0.2%
Cross-reactivity Group
para-amino-group
Reaction Type
contact-dermatitis
Source: SCCS; IVDK
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: (a) Hair dye substance in oxidative hair dye products (b) Products intended for colouring eyelashes.
BRIN Brazil/India Cosmetics
India: Restricted
Additional Ingredient Properties
2 property records from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "dye", "cross_reactivity_group": "para-amino-group", "patch_test_frequency_pct": "0.2", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "SCCS; IVDK"}
hair_dye
{"cas_number": "141-86-6", "ingredient_class": "oxidative_dye_precursor", "chemical_class": "other", "molecular_weight_Da": "109.13", "color_result_on_hair": "Brown", "shade_range": "brown", "primary_function": "precursor", "oxidative_dye_type": "primary_intermediate", "requires_developer": "yes", "permanence": "permanent", "oxidation_mechanism": "coupling", "hair_penetration_depth": "cortex", "se…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for 2,6-Diaminopyridine ⚠️.
Regulatory Flags
potential-allergen
eu_cosing_listed
Known Synonyms
5-22-11-00255
BRN 0108513
EINECS 205-507-2
UNII-K89AB8CKG6
Chemical Function
Dye
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL339234
Frequently Asked Questions
Is 2,6-Diaminopyridine ⚠️ allowed in the EU?
2,6-Diaminopyridine ⚠️ EU regulatory status: prohibited. Maximum allowed concentration: 0.3%. This is based on EU Regulation 1223/2009 and its amendments.
What does 2,6-Diaminopyridine ⚠️ do in cosmetics?
2,6-Diaminopyridine ⚠️ functions as: Hair dyeing (oxidative hair dye precursor, max 0.15% after mixing). It is classified as a cosmetic ingredient in our database. CAS number: 141-86-6.
Is 2,6-Diaminopyridine ⚠️ used outside cosmetics?
2,6-Diaminopyridine ⚠️ also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2,6-Diaminopyridine ⚠️ have different safety status in cosmetics vs industrial chemicals?
2,6-Diaminopyridine ⚠️ is prohibited in EU cosmetics at max 0.3% but has active industrial GHS classifications (H301, H315, H317, H319, H335, H411).
Compliance Tools
Check 2,6-Diaminopyridine ⚠️ compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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