Is Ginkgo Biloba Extract safe in cosmetics?
Ginkgo Biloba Extract has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Antioxidant
Ginkgo Biloba Extract
Also known as: Ginkgo biloba, ext., EINECS 289-896-4, UNII-19FUJ2C58T, Gingko biloba, Ginkgo leaf extract
INCI: GINKGO BILOBA LEAF EXTRACT
Ginkgo Biloba Extract (CAS 90045-36-6) is a cosmetic antioxidant functioning as Antioxidant; ginkgolides and flavonoids. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 90045-36-6 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant; ginkgolides and flavonoids
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Expert Panel (2024): Ginkgo Biloba Leaf Extract safe in current cosmetic practices when formulated to be non-sensitizing. Ginkgolic acid must stay below 5 ppm. Five leaf-derived ingredients confirmed safe; five others had insufficient data.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ginkgo Biloba Extract.
Calculate MoS for your specific formulation with the MoS Calculator.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
2B
Volume
108
Evaluation Year
2013
Additional Ingredient Properties
5 property records from structured ingredient metadata.
acne
{"cas_number": "90045-36-6", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restrictio…
anti_aging
{"anti_aging_claim": "antioxidant-protection, anti-wrinkle", "mechanism_of_action": "Flavonoids, terpenoids, free radical scavenging", "target_skin_layer": "epidermis", "collagen_stimulation": "No", "elastin_protection": "Mild", "wrinkle_reduction_pct": "5-12", "clinical_study_duration_weeks": "8", "sample_size": "30", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "Phyto…
anti_pollution
{"cas_number": "90045-36-6", "ingredient_class": "antioxidant_pollution_shield/anti_smog", "primary_mechanism": "free_radical_scavenging", "pollution_types_targeted": "PM2_5/UV_A/ozone/oxidative_stress", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "yes", "lipid_peroxidation_inhibition_pct": "75-…
depigmentation
{"cas_number": "90045-36-6", "ingredient_class": "combined_mechanism", "primary_mechanism_of_action": "Botanical extract with tyrosinase inhibition and/or antioxidant properties", "secondary_mechanisms": "Variable", "molecular_target": "other", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction_pct_c…
self_tanning
{"cas_number": "90045-36-6", "ingredient_class": "tan_extender", "tanning_mechanism": "other", "color_development_onset_hours": "0.0", "full_color_development_hours": "0", "color_duration_days": "0", "DHA_concentration_if_applicable_pct": "0", "erythrulose_concentration_pct": "0", "pH_dependent_color": "no", "formaldehyde_release_concern": "no", "formaldehyde_release_ppm": "0", "AGE_formation_conc…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Biocide
Deodorizer
Flavouring and nutrient
Fragrance
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Ginkgo Biloba Extract.
Regulatory Flags
cir-reviewed
no-sccs-opinion
ginkgolic-acid-limit
sensitization-conditional
purity-dependent-safety
Known Synonyms
Ginkgo biloba, ext.
EINECS 289-896-4
UNII-19FUJ2C58T
Gingko biloba
Ginkgo leaf extract
Chemical Function
Biocide
Antioxidant
Humectant
Deodorizer
Softener and conditioner
Flavouring and nutrient
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Ginkgo Biloba Extract allowed in the EU?
Ginkgo Biloba Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ginkgo Biloba Extract do in cosmetics?
Ginkgo Biloba Extract functions as: Antioxidant; ginkgolides and flavonoids. It is classified as a Antioxidant in our database. CAS number: 90045-36-6.
Compliance Tools
Check Ginkgo Biloba Extract compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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