Good Cosmetic Ingredient NOAEL Data

Glucoamylase

INCI: GLUCOAMYLASE

CAS Number
9032-08-0
Function
Skin conditioning (enzyme-based)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not restricted; enzyme ingredient; FDA GRAS as food processing aid

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Glucoamylase. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=1519.2 mg/kg bw/day oral rat oral REACH

Expert Verdict

SDS classifies as non-hazardous substance. Potential respiratory sensitizer in occupational dust exposure โ€” not a concern in finished cosmetics. Ensure microbial purity of fermentation-derived grades.

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Concern Level: Moderate

Regulatory Flags

potential-allergen eu_children_restricted

Frequently Asked Questions

Is Glucoamylase safe in cosmetics?

SDS classifies as non-hazardous substance. Potential respiratory sensitizer in occupational dust exposure โ€” not a concern in finished cosmetics. Ensure microbial purity of fermentation-derived grades. The EU classifies Glucoamylase as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is Glucoamylase allowed in the EU?

Glucoamylase EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Glucoamylase do in cosmetics?

Glucoamylase functions as: Skin conditioning (enzyme-based). It is classified as a cosmetic ingredient in our database. CAS number: 9032-08-0.

What is the Margin of Safety for Glucoamylase?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Glucoamylase?

The NOAEL (No Observed Adverse Effect Level) for Glucoamylase is >=1519.2 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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