Glucoheptonic Acid

INCI: GLUCOHEPTONIC ACID

CAS Number
23351-80-0 (D-glycero-D-gulo-heptonic acid)
Function
Chelating agent; skin conditioning (related to Glucoheptonolactone via hydrolysis)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not restricted under 21 CFR; no standalone CIR monograph

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Glucoheptonic acid is the hydrolyzed open-chain form of Glucoheptonolactone; equilibrates in solution. No standalone HRIPT, dermal absorption, or margin of safety data available. CIR (2022) found insufficient data for the lactone form and did not accept read-across from gluconic acid pathway without manufacturing/impurity data.

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Concern Level: Moderate

Frequently Asked Questions

Is Glucoheptonic Acid safe in cosmetics?

Glucoheptonic acid is the hydrolyzed open-chain form of Glucoheptonolactone; equilibrates in solution. No standalone HRIPT, dermal absorption, or margin of safety data available. CIR (2022) found insufficient data for the lactone form and did not accept read-across from gluconic acid pathway without manufacturing/impurity data. The EU classifies Glucoheptonic Acid as "permitted". Safety rating: MODERATE.

Is Glucoheptonic Acid allowed in the EU?

Glucoheptonic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Glucoheptonic Acid do in cosmetics?

Glucoheptonic Acid functions as: Chelating agent; skin conditioning (related to Glucoheptonolactone via hydrolysis). It is classified as a cosmetic ingredient in our database. CAS number: 23351-80-0 (D-glycero-D-gulo-heptonic acid).

What is the Margin of Safety for Glucoheptonic Acid?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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