Good Cosmetic Ingredient

Glucosamine Sulfate

INCI: GLUCOSAMINE SULFATE

CAS Number
29031-19-4
Function
Skin Conditioning
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No specific FDA restrictions; zero formulations reported in FDA VCRP; sold as dietary supplement under DSHEA

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

CIR Expert Panel (June 2022) concluded safe in present practices of use when formulated to be non-irritating; no EU or FDA restrictions; industry prefers Acetyl Glucosamine or Glucosamine HCl with no established use-concentration benchmark for sulfate form; tyrosinase inhibition mechanism may trigger drug-claim risk if marketed for pigmentation

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Concern Level: Low

Regulatory Flags

cir-approved skin-conditioning humectant hyaluronic-acid-precursor tyrosinase-inhibition pigmentation-claim-risk zero-vcrp-use highly-hydrophilic

Frequently Asked Questions

Is Glucosamine Sulfate safe in cosmetics?

CIR Expert Panel (June 2022) concluded safe in present practices of use when formulated to be non-irritating; no EU or FDA restrictions; industry prefers Acetyl Glucosamine or Glucosamine HCl with no established use-concentration benchmark for sulfate form; tyrosinase inhibition mechanism may trigger drug-claim risk if marketed for pigmentation The EU classifies Glucosamine Sulfate as "permitted". Safety rating: GOOD.

Is Glucosamine Sulfate allowed in the EU?

Glucosamine Sulfate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Glucosamine Sulfate do in cosmetics?

Glucosamine Sulfate functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 29031-19-4.

What is the Margin of Safety for Glucosamine Sulfate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Glucosamine Sulfate compliance across multiple jurisdictions:

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Ingredient Decoder
Paste a full ingredient list for instant analysis
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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