Glucuronic Acid

INCI: GLUCURONIC ACID

CAS Number
576-37-4
Function
Buffering, Chelating, Humectant
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No CIR monograph; not independently GRAS listed; endogenous human metabolite produced via hepatic glucuronidation

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Permitted unrestricted EU ingredient with no Annex listings; endogenous metabolite with favorable safety profile but limited toxicological data package.

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Concern Level: Low

Regulatory Flags

data-gap endogenous-metabolite no-sccs-opinion no-cir-monograph humectant chelating buffering

Frequently Asked Questions

Is Glucuronic Acid safe in cosmetics?

Permitted unrestricted EU ingredient with no Annex listings; endogenous metabolite with favorable safety profile but limited toxicological data package. The EU classifies Glucuronic Acid as "permitted". Safety rating: GOOD.

Is Glucuronic Acid allowed in the EU?

Glucuronic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Glucuronic Acid do in cosmetics?

Glucuronic Acid functions as: Buffering, Chelating, Humectant. It is classified as a cosmetic ingredient in our database. CAS number: 576-37-4.

What is the Margin of Safety for Glucuronic Acid?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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