Glycosaminoglycans

INCI: GLYCOSAMINOGLYCANS

CAS Number
No single CAS (class); Hydrolyzed GAGs: 156715-51-4
Function
Skin conditioning, humectant, moisturizing
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no 21 CFR restriction; sodium hyaluronate extensively CIR-reviewed

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

BSE/TSE concern if animal-derived (rooster comb, bovine sources) โ€” biofermentation-derived preferred; hydrolyzed/low-MW forms penetrate deeper and may cause transient inflammation at very high concentrations; specify MW range in CPSR

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Concern Level: Low

Frequently Asked Questions

Is Glycosaminoglycans safe in cosmetics?

BSE/TSE concern if animal-derived (rooster comb, bovine sources) โ€” biofermentation-derived preferred; hydrolyzed/low-MW forms penetrate deeper and may cause transient inflammation at very high concentrations; specify MW range in CPSR The EU classifies Glycosaminoglycans as "permitted". Safety rating: EXCELLENT.

Is Glycosaminoglycans allowed in the EU?

Glycosaminoglycans EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Glycosaminoglycans do in cosmetics?

Glycosaminoglycans functions as: Skin conditioning, humectant, moisturizing. It is classified as a cosmetic ingredient in our database. CAS number: No single CAS (class); Hydrolyzed GAGs: 156715-51-4.

What is the Margin of Safety for Glycosaminoglycans?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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