Glycyrrhetinyl Stearate

INCI: GLYCYRRHETINYL STEARATE

CAS Number
4827-59-2
Function
Humectant, skin conditioning
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no CFR restriction; covered under CIR assessment of Glycyrrhetinic Acid and its esters as safe

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Minimal. Ester form is expected to hydrolyze slowly; systemic exposure negligible. High MW limits skin penetration.

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Concern Level: Low

Frequently Asked Questions

Is Glycyrrhetinyl Stearate safe in cosmetics?

Minimal. Ester form is expected to hydrolyze slowly; systemic exposure negligible. High MW limits skin penetration. The EU classifies Glycyrrhetinyl Stearate as "permitted". Safety rating: EXCELLENT.

Is Glycyrrhetinyl Stearate allowed in the EU?

Glycyrrhetinyl Stearate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Glycyrrhetinyl Stearate do in cosmetics?

Glycyrrhetinyl Stearate functions as: Humectant, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 4827-59-2.

What is the Margin of Safety for Glycyrrhetinyl Stearate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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