Is Guanidine Carbonate safe in cosmetics?
Guanidine Carbonate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Guanidine Carbonate
Also known as: Carbonic acid, compd. with guanidine (1:2), Bisguanidinium carbonate, EINECS 209-813-7, Guanidinium carbonate, NSC 2171 (+2 more)
INCI: GUANIDINE CARBONATE
Guanidine Carbonate (CAS 593-85-1) is a cosmetic cosmetic ingredient functioning as Buffering agent, pH adjuster; used in no-lye hair relaxer systems. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 593-85-1 →
Auto-generated CPSR Part A draft with source citations
Function
Buffering agent, pH adjuster; used in no-lye hair relaxer systems
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
carbonic acid;bis(guanidine)
InChIKey
STIAPHVBRDNOAJ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — not restricted under 21 CFR Parts 700–740
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Guanidine Carbonate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "593-85-1", "ingredient_class": "other", "chemical_class": "other", "molecular_weight_Da": "180.17", "color_result_on_hair": "Alkalizer in no-lye relaxers", "primary_function": "modifier", "requires_developer": "no", "sensitization_risk": "moderate", "scalp_irritation_potential": "moderate", "hair_damage_level": "moderate", "vegan": "yes", "typical_use_level_pct": "5-15", "cost_tier…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Hair waving or straightening
Softener and conditioner
pH regulating agent
Expert Verdict
Expert safety assessment and concern-level summary for Guanidine Carbonate.
Known Synonyms
Carbonic acid, compd. with guanidine (1:2)
Bisguanidinium carbonate
EINECS 209-813-7
Guanidinium carbonate
NSC 2171
Guanidine carbonate (2:1)
UNII-V3394X3G2W
Chemical Function
Softener and conditioner
pH regulating agent
Hair waving or straightening
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3187576
Frequently Asked Questions
Is Guanidine Carbonate allowed in the EU?
Guanidine Carbonate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Guanidine Carbonate do in cosmetics?
Guanidine Carbonate functions as: Buffering agent, pH adjuster; used in no-lye hair relaxer systems. It is classified as a cosmetic ingredient in our database. CAS number: 593-85-1.
Is Guanidine Carbonate used outside cosmetics?
Guanidine Carbonate also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Guanidine Carbonate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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