Is Guanadinium Carbonate safe in cosmetics?
Guanadinium Carbonate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Guanadinium Carbonate
Also known as: Carbonic acid, compd. with guanidine (1:2), Bisguanidinium carbonate, EINECS 209-813-7, Guanidinium carbonate, NSC 2171 (+2 more)
INCI: GUANIDINE CARBONATE
Guanadinium Carbonate (CAS 593-85-1) is a cosmetic cosmetic ingredient functioning as pH adjuster, buffering agent, hair conditioning, depilatory aid. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 593-85-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Guanadinium Carbonate is classified GHS Danger (H302, H315, H318, H319, H335, H412) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
pH adjuster, buffering agent, hair conditioning, depilatory aid
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
carbonic acid;bis(guanidine)
InChIKey
STIAPHVBRDNOAJ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA prohibited/restricted list; used as pH adjuster and depilatory aid; strong alkalinity requires careful formulation
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Guanadinium Carbonate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "593-85-1", "ingredient_class": "other", "chemical_class": "other", "molecular_weight_Da": "180.17", "color_result_on_hair": "Alkalizer in no-lye relaxers", "primary_function": "modifier", "requires_developer": "no", "sensitization_risk": "moderate", "scalp_irritation_potential": "moderate", "hair_damage_level": "moderate", "vegan": "yes", "typical_use_level_pct": "5-15", "cost_tier…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Hair waving or straightening
Softener and conditioner
pH regulating agent
Expert Verdict
Expert safety assessment and concern-level summary for Guanadinium Carbonate.
Regulatory Flags
ph-adjuster
alkaline
depilatory
buffering
Known Synonyms
Carbonic acid, compd. with guanidine (1:2)
Bisguanidinium carbonate
EINECS 209-813-7
Guanidinium carbonate
NSC 2171
Guanidine carbonate (2:1)
UNII-V3394X3G2W
Chemical Function
Softener and conditioner
pH regulating agent
Hair waving or straightening
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3187576
Frequently Asked Questions
Is Guanadinium Carbonate allowed in the EU?
Guanadinium Carbonate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Guanadinium Carbonate do in cosmetics?
Guanadinium Carbonate functions as: pH adjuster, buffering agent, hair conditioning, depilatory aid. It is classified as a cosmetic ingredient in our database. CAS number: 593-85-1.
Is Guanadinium Carbonate used outside cosmetics?
Guanadinium Carbonate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Guanadinium Carbonate have different safety status in cosmetics vs industrial chemicals?
Guanadinium Carbonate is classified GHS Danger (H302, H315, H318, H319, H335, H412) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Guanadinium Carbonate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Decylene/Butylene Glycol
Excellent
Same category
Skin Conditioning, Humectant, Solvent...
Diglycerin
Excellent
Same category
Humectant
Disodium Adenosine Triphosphate
Excellent
Same category
Skin conditioning
Fructose Bisphosphate
Excellent
Same category
Skin Conditioning, Cellular Energy Su...
Glucono Delta-Lactone
Excellent
Same category
pH adjuster, chelating agent, humecta...
Hydroxyethyl Urea
Excellent
Same category
Humectant, Moisturizing, Skin Conditi...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
Guanidine Carbonate
Moderate
Chemical family
Buffering agent, pH adjuster; used in...
Myricyl Alcohol
Excellent
Chemical family
Viscosity controlling
OCTADECANE
Good
Chemical family
Perfuming, Skin Conditioning, Skin Co...
Is Guanadinium Carbonate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Guanadinium Carbonate in your formulation.