Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Guanidine HCl. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
GHS H302+H332 (harmful if swallowed/inhaled), H315 (skin irritation), H319 (serious eye irritation). Protein-denaturing activity means it can compromise the skin barrier at high concentrations. Rinse-off use preferred.
Frequently Asked Questions
Is Guanidine HCl safe in cosmetics?
GHS H302+H332 (harmful if swallowed/inhaled), H315 (skin irritation), H319 (serious eye irritation). Protein-denaturing activity means it can compromise the skin barrier at high concentrations. Rinse-off use preferred. The EU classifies Guanidine HCl as "permitted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.
Is Guanidine HCl allowed in the EU?
Guanidine HCl EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Guanidine HCl do in cosmetics?
Guanidine HCl functions as: Denaturant, pH adjuster; protein denaturant in hair-care applications. It is classified as a cosmetic ingredient in our database. CAS number: 50-01-1.
What is the Margin of Safety for Guanidine HCl?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Guanidine HCl?
The NOAEL (No Observed Adverse Effect Level) for Guanidine HCl is 100 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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Related Ingredients
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