Halocidin Subunit A Amide/Halocidin Subunit B Amide

INCI: HALOCIDIN SUBUNIT A AMIDE/HALOCIDIN SUBUNIT B AMIDE

CAS Number
Parent halocidin CAS 45272204; specific cosmetic-grade CAS for the A/B amide complex is not separately assigned
Function
Antimicrobial, skin conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed; no specific prohibition; falls under general cosmetic peptide ingredients

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Limited long-term safety data in cosmetic use; peptide-based ingredient - potential for sensitization in individuals with marine protein allergies; derived from marine invertebrate hemocytes. Derived from the tunicate Halocynthia aurantium; the native peptide is a heterodimer of an 18-amino-acid subunit A (WLNALLHHGLNCAKGVLA) and a 15-amino-acid subunit B (ALLHHGLNCAKGVLA), linked by a disulfide bond. Demonstrates activity against MRSA and multidrug-resistant Pseudomonas aeruginosa. The amide...

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Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Halocidin Subunit A Amide/Halocidin Subunit B Amide safe in cosmetics?

Limited long-term safety data in cosmetic use; peptide-based ingredient - potential for sensitization in individuals with marine protein allergies; derived from marine invertebrate hemocytes. Derived from the tunicate Halocynthia aurantium; the native peptide is a heterodimer of an 18-amino-acid subunit A (WLNALLHHGLNCAKGVLA) and a 15-amino-acid subunit B (ALLHHGLNCAKGVLA), linked by a disulfide bond. Demonstrates activity against MRSA and multidrug-resistant Pseudomonas aeruginosa. The amide... The EU classifies Halocidin Subunit A Amide/Halocidin Subunit B Amide as "permitted". Safety rating: MODERATE.

Is Halocidin Subunit A Amide/Halocidin Subunit B Amide allowed in the EU?

Halocidin Subunit A Amide/Halocidin Subunit B Amide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Halocidin Subunit A Amide/Halocidin Subunit B Amide do in cosmetics?

Halocidin Subunit A Amide/Halocidin Subunit B Amide functions as: Antimicrobial, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Parent halocidin CAS 45272204; specific cosmetic-grade CAS for the A/B amide complex is not separately assigned.

What is the Margin of Safety for Halocidin Subunit A Amide/Halocidin Subunit B Amide?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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