Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for HC Red No. 14. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 50 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
As a nitroaminobenzoxazine, standard concerns apply regarding potential sensitization and possible nitrosamine impurity formation. Must meet specified purity criteria.. The benzoxazine ring system provides structural stability and good color fastness on hair. Produces red shades in combination with other direct dyes.
Regulatory Flags
Frequently Asked Questions
Is HC Red No. 14 safe in cosmetics?
As a nitroaminobenzoxazine, standard concerns apply regarding potential sensitization and possible nitrosamine impurity formation. Must meet specified purity criteria.. The benzoxazine ring system provides structural stability and good color fastness on hair. Produces red shades in combination with other direct dyes. The EU classifies HC Red No. 14 as "restricted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.
Is HC Red No. 14 allowed in the EU?
HC Red No. 14 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does HC Red No. 14 do in cosmetics?
HC Red No. 14 functions as: Hair dyeing - direct dye for semi-permanent hair color formulations. It is classified as a cosmetic ingredient in our database. CAS number: 99788-75-7.
What is the Margin of Safety for HC Red No. 14?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for HC Red No. 14?
The NOAEL (No Observed Adverse Effect Level) for HC Red No. 14 is 50 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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