Is HC Violet No. 2 safe in cosmetics?
HC Violet No. 2 has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
HC Violet No. 2
Also known as: UNII-639H4QR04O, 1-gamma-Hydroxypropylamino-2-nitro-4-bis(beta-hydroxyethyl)aminobenzene, 1-Propanol, 3-((4-(bis(2-hydroxyethyl)amino)-2-nitrophenyl)amino)-, HC Violet 2, Imexine FAG
INCI: HC VIOLET NO. 2
HC Violet No. 2 (CAS 104226-19-9) is a cosmetic cosmetic ingredient functioning as Hair dyeing (colorant). Reported NOAEL =50 mg/kg bw/d (SCCS_vision_codex); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 104226-19-9 →
Auto-generated CPSR Part A draft with source citations
Function
Hair dyeing (colorant)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
3-[4-[bis(2-hydroxyethyl)amino]-2-nitroanilino]propan-1-ol
InChIKey
YHSOWKGIYXECIF-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted under coal tar hair dye exemption (FD&C Act §601(a))
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for HC Violet No. 2.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for HC Violet No. 2. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =50 mg/kg bw/d | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =50 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =50 mg/kg bw/d | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =50 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =50 mg/kg bw/d | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =50 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =50 mg/kg bw/d | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =50 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =2500 mg/kg bw/d | oral | human | NOAEL study | SCCS_vision_codex |
| NOAEL | =2500 mg/kg bw/d | oral | human | NOAEL study | SCCS_vision_codex |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Skin Sens. 1; Aquatic Chronic 3
Hazard Statements
- H317 May cause an allergic skin reaction
- H412 Harmful to aquatic life with long lasting effects
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance in non-oxidative hair dye products. Max: 0.02.
BRIN Brazil/India Cosmetics
India: Restricted · max 0.02
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (1 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 1.93% | - | - | SCCP/1081/07 |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "104226-19-9", "ingredient_class": "direct_dye", "chemical_class": "nitro", "molecular_weight_Da": "226.23", "color_result_on_hair": "Violet", "shade_range": "fashion_color", "primary_function": "direct_deposit", "requires_developer": "no", "lift_capability_levels": "0", "deposit_only": "yes", "permanence": "semi_permanent", "wash_fastness_shampoos": "6-12", "light_fastness": "moder…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (2)
EU Restricted for Children (Cosmetics)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for HC Violet No. 2.
Regulatory Flags
colorant
eu_children_restricted
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to HC Violet No. 2 by CAS number or substance name.
Studies
12
Lowest NOAEL
50
Highest NOAEL
2500
Units vary across source rows: mg/kg bw/d, mg/kg bw
SCCS_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 1.93% | SCCS opinion extraction | - |
Known Synonyms
UNII-639H4QR04O
1-gamma-Hydroxypropylamino-2-nitro-4-bis(beta-hydroxyethyl)aminobenzene
1-Propanol, 3-((4-(bis(2-hydroxyethyl)amino)-2-nitrophenyl)amino)-
HC Violet 2
Imexine FAG
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
children; Europe; Personal care
children; Europe; Personal care
children; Europe; Personal care
Frequently Asked Questions
Is HC Violet No. 2 allowed in the EU?
HC Violet No. 2 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does HC Violet No. 2 do in cosmetics?
HC Violet No. 2 functions as: Hair dyeing (colorant). It is classified as a cosmetic ingredient in our database. CAS number: 104226-19-9.
What is the NOAEL for HC Violet No. 2?
The NOAEL (No Observed Adverse Effect Level) for HC Violet No. 2 is =50 mg/kg bw/d based on a NOAEL study study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Is HC Violet No. 2 used outside cosmetics?
HC Violet No. 2 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check HC Violet No. 2 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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