Moderate Cosmetic Ingredient

Hedeoma pulegioides (American Pennyroyal) Herb Oil

INCI: HEDEOMA PULEGIOIDES (AMERICAN PENNYROYAL) HERB OIL

CAS Number
8007-44-1
Function
Fragrance ingredient; historically also used for insect-repellent and tonic properties
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes Listed in 21 CFR 172.510 for food flavoring. No specific cosmetic prohibition, but the documented lethal hepatotoxicity creates serious regulatory and liability exposure.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Severe hepatotoxicity. Pulegone content ranges 62-97%. A plausible mechanism for liver toxicity involving pulegone and menthofuran metabolic activation has been established. Historical use as an abortifacient adds reproductive toxicity concerns.. Steam-distilled essential oil from the aerial parts of Hedeoma pulegioides. Distinguished from European pennyroyal oil (Mentha pulegium, CAS 8013-99-8) by botanical source but sharing the same toxicological profile.

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Concern Level: High

Regulatory Flags

plant-oil fragrance-component fda_food_additive

Frequently Asked Questions

Is Hedeoma pulegioides (American Pennyroyal) Herb Oil safe in cosmetics?

Severe hepatotoxicity. Pulegone content ranges 62-97%. A plausible mechanism for liver toxicity involving pulegone and menthofuran metabolic activation has been established. Historical use as an abortifacient adds reproductive toxicity concerns.. Steam-distilled essential oil from the aerial parts of Hedeoma pulegioides. Distinguished from European pennyroyal oil (Mentha pulegium, CAS 8013-99-8) by botanical source but sharing the same toxicological profile. The EU classifies Hedeoma pulegioides (American Pennyroyal) Herb Oil as "prohibited". Safety rating: MODERATE.

Is Hedeoma pulegioides (American Pennyroyal) Herb Oil allowed in the EU?

Hedeoma pulegioides (American Pennyroyal) Herb Oil EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Hedeoma pulegioides (American Pennyroyal) Herb Oil do in cosmetics?

Hedeoma pulegioides (American Pennyroyal) Herb Oil functions as: Fragrance ingredient; historically also used for insect-repellent and tonic properties. It is classified as a cosmetic ingredient in our database. CAS number: 8007-44-1.

What is the Margin of Safety for Hedeoma pulegioides (American Pennyroyal) Herb Oil?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Hedeoma pulegioides (American Pennyroyal) Herb Oil compliance across multiple jurisdictions:

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