HEMA Trimellitate Anhydride

INCI: HEMA TRIMELLITATE ANHYDRIDE

CAS Number
Not publicly assigned in CosIng
Function
Film forming (nail enhancement)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no CFR prohibition; not individually CIR-reviewed

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Trimellitic anhydride (TMA) is a well-documented occupational sensitizer causing pulmonary and dermal hypersensitivity; combined with HEMA sensitization, this ingredient carries elevated risk with no cosmetic-specific toxicology dossier available; patch testing and residual anhydride specification strongly recommended.

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Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is HEMA Trimellitate Anhydride safe in cosmetics?

Trimellitic anhydride (TMA) is a well-documented occupational sensitizer causing pulmonary and dermal hypersensitivity; combined with HEMA sensitization, this ingredient carries elevated risk with no cosmetic-specific toxicology dossier available; patch testing and residual anhydride specification strongly recommended. The EU classifies HEMA Trimellitate Anhydride as "permitted". Safety rating: MODERATE.

Is HEMA Trimellitate Anhydride allowed in the EU?

HEMA Trimellitate Anhydride EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does HEMA Trimellitate Anhydride do in cosmetics?

HEMA Trimellitate Anhydride functions as: Film forming (nail enhancement). It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned in CosIng.

What is the Margin of Safety for HEMA Trimellitate Anhydride?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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