Is Hematin safe in cosmetics?
Hematin has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
MODERATE
Cosmetic Ingredient
Hematin
Also known as: Ferrate(2-), [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN21,κN22,κN23,κN24]hydroxy-, hydrogen (1:2), (SP-5-13)-, Iron, [dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-)]hydroxy-, Ferrate(2-), [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24]hydroxy-, dihydrogen, (SP-5-13)-, Ferrihemic acid
INCI: HEMATIN
Hematin (CAS 15489-90-4) is a cosmetic cosmetic ingredient functioning as Hair conditioning / colorant (iron-porphyrin complex). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 15489-90-4 →
Function
Hair conditioning / colorant (iron-porphyrin complex)
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,23-diid-2-yl]propanoic acid;iron(2+);hydrate
InChIKey
CODDGSIFXYHHJO-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — not listed as prohibited; if used as colorant, would require FDA color additive approval
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hematin.
Calculate MoS for your specific formulation with the MoS Calculator.
Editorial summary
Preliminary editorial summary for Hematin — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
colorant
Known Synonyms
Ferrate(2-), [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN21,κN22,κN23,κN24]hydroxy-, hydrogen (1:2), (SP-5-13)-
Iron, [dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-)]hydroxy-
Ferrate(2-), [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24]hydroxy-, dihydrogen, (SP-5-13)-
Ferrihemic acid
Regulatory Lists
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
hematin
ChEMBL ID
CHEMBL3707238
Frequently Asked Questions
Is Hematin allowed in the EU?
Hematin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hematin do in cosmetics?
Hematin functions as: Hair conditioning / colorant (iron-porphyrin complex). It is classified as a cosmetic ingredient in our database. CAS number: 15489-90-4.
Is Hematin used outside cosmetics?
Hematin also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Hematin compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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