Glutathione
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
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Dermal Penetration Profile
Skin absorption and penetration characteristics of Glutathione, relevant to systemic exposure and MoS calculations.
Source: J Cosmet Dermatol 2017
Expert Verdict
Glutathione is the master intracellular antioxidant and central mediator of phase II detoxification, enabling skin to metabolize and neutralize reactive pollutant metabolites. Topical delivery is the primary challenge; liposomal reduced glutathione (L-GSH) or S-acetyl-glutathione forms are recommended for cosmetic formulations. Synergizes with vitamin C and niacinamide; combine with ectoin and vitamin C for comprehensive oxidative defense and phase II detox support.
Regulatory Flags
Frequently Asked Questions
Is Glutathione safe in cosmetics?
Glutathione is the master intracellular antioxidant and central mediator of phase II detoxification, enabling skin to metabolize and neutralize reactive pollutant metabolites. Topical delivery is the primary challenge; liposomal reduced glutathione (L-GSH) or S-acetyl-glutathione forms are recommended for cosmetic formulations. Synergizes with vitamin C and niacinamide; combine with ectoin and vitamin C for comprehensive oxidative defense and phase II detox support. The EU classifies Glutathione as "permitted". Safety rating: EXCELLENT.
Is Glutathione allowed in the EU?
Glutathione EU regulatory status: permitted. Maximum allowed concentration: 0.1–2%. This is based on EU Regulation 1223/2009 and its amendments.
What does Glutathione do in cosmetics?
Glutathione functions as: Fragrance; Reducing agent. It is classified as a Antioxidant in our database. CAS number: 70-18-8.
What is the Margin of Safety for Glutathione?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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