Moderate Cosmetic Ingredient Dermal Penetration

Hexapeptide-11

INCI: HEXAPEPTIDE-11

CAS Number
Not publicly assigned
Function
Skin Conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no CFR prohibition

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Dermal Penetration Profile

Skin absorption and penetration characteristics of Hexapeptide-11, relevant to systemic exposure and MoS calculations.

Absorption %
1-3%
Penetration Level
surface
Penetration Depth
stratum corneum
Molecular Weight
673.8 Da
Log P
-0.8
Systemic Absorption
minimal
Topical Bioavailability
0.5-2%
Safety Margin Factor
minimal
Vehicle Dependent
Yes โ€” absorption varies by formulation

Source: Cosmetic Science

Expert Verdict

No published toxicological dossier; amino acid sequence not publicly defined; cannot read-across to hexapeptide-12 without confirmed sequence homology; CIR Panel explicitly warned against grouping peptides with undefined sequences.

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Concern Level: Moderate

Frequently Asked Questions

Is Hexapeptide-11 safe in cosmetics?

No published toxicological dossier; amino acid sequence not publicly defined; cannot read-across to hexapeptide-12 without confirmed sequence homology; CIR Panel explicitly warned against grouping peptides with undefined sequences. The EU classifies Hexapeptide-11 as "permitted". Safety rating: MODERATE.

Is Hexapeptide-11 allowed in the EU?

Hexapeptide-11 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hexapeptide-11 do in cosmetics?

Hexapeptide-11 functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned.

What is the Margin of Safety for Hexapeptide-11?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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