Is Hexapeptide-11 safe in cosmetics?
Hexapeptide-11 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Hexapeptide-11
INCI: HEXAPEPTIDE-11
Hexapeptide-11 (CAS Not publicly assigned) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS Not publicly assigned →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no CFR prohibition
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexapeptide-11.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Hexapeptide-11, relevant to systemic exposure and MoS calculations.
Absorption %
1-3%
Penetration Level
surface
Penetration Depth
stratum corneum
Molecular Weight
673.8 Da
Log P
-0.8
Systemic Absorption
minimal
Topical Bioavailability
0.5-2%
Safety Margin Factor
minimal
Vehicle Dependent
Yes — absorption varies by formulation
Source: Cosmetic Science
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_acne": "No restriction", "c…
anti_aging
{"anti_aging_claim": "anti-wrinkle, firming", "mechanism_of_action": "Stimulates collagen, elastin synthesis", "target_skin_layer": "dermis", "collagen_stimulation": "Yes", "elastin_protection": "Yes", "wrinkle_reduction_pct": "12-20", "clinical_study_duration_weeks": "8", "sample_size": "28", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "Cosmetic research", "improvement…
anti_pollution
{"cas_number": "161258-30-6", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibi…
concentration
{"min_concentration_pct": "0.001", "max_concentration_pct": "0.5", "typical_concentration_pct": "0.05", "product_type": "Serum", "function_at_concentration": "Collagen synthesis, firming", "source": "Supplier TDS"}
cost_pricing
{"cost_tier": "luxury", "estimated_cost_per_kg_usd_low": "13000", "estimated_cost_per_kg_usd_high": "22000", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "low", "primary_source_region": "Global (synthetic)", "bulk_discount_threshold_kg": "1", "seasonal_price_variation": "low", "commodity_or_specialty": "specialty", "substitute_ingredients": "P…
dermal_absorption
{"molecular_weight_da": "673.8", "log_p_value": "-0.8", "skin_penetration_level": "surface", "penetration_depth": "stratum corneum", "absorption_pct": "1-3", "systemic_absorption": "minimal", "penetration_enhancer": "no", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "neutral", "bioavailability_topical_pct": "0.5-2", "safety_margin_factor": "minimal", "source": "Cosm…
peptide
{"cas_number": "868844-74-0", "trade_name": "Peptamide-6", "peptide_sequence_amino_acids": "Ala-Asp-Asp-Leu-Leu-Pro", "peptide_length_residues": "6", "molecular_weight_daltons": "672.7", "peptide_class": "signal", "mechanism_of_action": "Enhances cell adhesion and wound healing", "target_protein_or_receptor": "Integrin receptors", "biomimetic_of": "fibronectin", "collagen_stimulation_type": "I/III…
ph_stability
{"optimal_ph_min": "5.5", "optimal_ph_max": "6.5", "stable_ph_min": "5.0", "stable_ph_max": "7.0", "degrades_above_ph": "7.5", "degrades_below_ph": "4.5", "ph_dependent_function": "Skin conditioning", "formulation_note": "Standard peptide pH stability", "source": "Vivify 2026"}
Expert Verdict
Expert safety assessment and concern-level summary for Hexapeptide-11.
Frequently Asked Questions
Is Hexapeptide-11 allowed in the EU?
Hexapeptide-11 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexapeptide-11 do in cosmetics?
Hexapeptide-11 functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned.
Compliance Tools
Check Hexapeptide-11 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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