Regulatory Status
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Safety Data
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Expert Verdict
Hexapeptide-4 (Phe-Gly-His-Sta-Ala-Phe-OMe) contains statine, a modified amino acid, and histidine; verify no histamine liberation at use levels. Myristoyl derivative increases lipophilicity and skin penetration.
Frequently Asked Questions
Is Hexapeptide-4 safe in cosmetics?
Hexapeptide-4 (Phe-Gly-His-Sta-Ala-Phe-OMe) contains statine, a modified amino acid, and histidine; verify no histamine liberation at use levels. Myristoyl derivative increases lipophilicity and skin penetration. The EU classifies Hexapeptide-4 as "permitted". Safety rating: MODERATE.
Is Hexapeptide-4 allowed in the EU?
Hexapeptide-4 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexapeptide-4 do in cosmetics?
Hexapeptide-4 functions as: Skin conditioning — stimulates collagen IV/VII, fibronectin, elastin synthesis; inhibits MMP-1. It is classified as a cosmetic ingredient in our database. CAS number: 112317-45-0.
What is the Margin of Safety for Hexapeptide-4?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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