Hexapeptide-48

INCI: HEXAPEPTIDE-48

CAS Number
Not publicly assigned for free base
Function
Skin conditioning; acts on delta-opioid receptors (DOR) to modulate inflammation
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not prohibited or restricted under 21 CFR; no CIR monograph

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Opioid receptor activity is a notable concern; CPSR assessor should evaluate pharmacological activity versus cosmetic claim boundary and ensure concentration remains within cosmetic-grade range.

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Concern Level: Moderate

Frequently Asked Questions

Is Hexapeptide-48 safe in cosmetics?

Opioid receptor activity is a notable concern; CPSR assessor should evaluate pharmacological activity versus cosmetic claim boundary and ensure concentration remains within cosmetic-grade range. The EU classifies Hexapeptide-48 as "permitted". Safety rating: MODERATE.

Is Hexapeptide-48 allowed in the EU?

Hexapeptide-48 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hexapeptide-48 do in cosmetics?

Hexapeptide-48 functions as: Skin conditioning; acts on delta-opioid receptors (DOR) to modulate inflammation. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned for free base.

What is the Margin of Safety for Hexapeptide-48?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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