Hexapeptide-69 D-Tryptophanyl Dipeptide-47 Amide

INCI: HEXAPEPTIDE-69 D-TRYPTOPHANYL DIPEPTIDE-47 AMIDE

CAS Number
Not assigned / not publicly listed
Function
Skin conditioning; complex peptide-amide conjugate
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not prohibited or restricted under 21 CFR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

D-amino acid incorporation may resist proteolytic degradation, potentially increasing bioavailability and residence time; multi-peptide conjugate with amide bond lacks published safety data for this specific architecture. D-tryptophan residue absorbs UV at 280 nm and phototoxicity assessment may be warranted. No CIR or SCCS review available.

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Concern Level: High

Frequently Asked Questions

Is Hexapeptide-69 D-Tryptophanyl Dipeptide-47 Amide safe in cosmetics?

D-amino acid incorporation may resist proteolytic degradation, potentially increasing bioavailability and residence time; multi-peptide conjugate with amide bond lacks published safety data for this specific architecture. D-tryptophan residue absorbs UV at 280 nm and phototoxicity assessment may be warranted. No CIR or SCCS review available. The EU classifies Hexapeptide-69 D-Tryptophanyl Dipeptide-47 Amide as "permitted". Safety rating: MODERATE.

Is Hexapeptide-69 D-Tryptophanyl Dipeptide-47 Amide allowed in the EU?

Hexapeptide-69 D-Tryptophanyl Dipeptide-47 Amide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hexapeptide-69 D-Tryptophanyl Dipeptide-47 Amide do in cosmetics?

Hexapeptide-69 D-Tryptophanyl Dipeptide-47 Amide functions as: Skin conditioning; complex peptide-amide conjugate. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned / not publicly listed.

What is the Margin of Safety for Hexapeptide-69 D-Tryptophanyl Dipeptide-47 Amide?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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