Hexapeptide-9

INCI: HEXAPEPTIDE-9

CAS Number
1228371-11-6
Function
Skin conditioning — anti-aging; stimulates collagen I, III, IV synthesis; boosts laminin-5, integrins; strengthens dermal-epidermal junction (DEJ)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — not restricted under 21 CFR; no dedicated CIR review published

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

No CIR or SCCS opinion. Commercially available from multiple suppliers (Collaxyl™ IS) but safety assessment relies on peptide class read-across. A CPSR Safety Assessor may require supplier tox data or formal read-across justification.

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Concern Level: Moderate

Frequently Asked Questions

Is Hexapeptide-9 safe in cosmetics?

No CIR or SCCS opinion. Commercially available from multiple suppliers (Collaxyl™ IS) but safety assessment relies on peptide class read-across. A CPSR Safety Assessor may require supplier tox data or formal read-across justification. The EU classifies Hexapeptide-9 as "permitted". Safety rating: MODERATE.

Is Hexapeptide-9 allowed in the EU?

Hexapeptide-9 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hexapeptide-9 do in cosmetics?

Hexapeptide-9 functions as: Skin conditioning — anti-aging; stimulates collagen I, III, IV synthesis; boosts laminin-5, integrins; strengthens dermal-epidermal junction (DEJ). It is classified as a cosmetic ingredient in our database. CAS number: 1228371-11-6.

What is the Margin of Safety for Hexapeptide-9?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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