Is Hexapeptide-9 safe in cosmetics?
Hexapeptide-9 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
MODERATE
Cosmetic Ingredient
Hexapeptide-9
INCI: HEXAPEPTIDE-9
Hexapeptide-9 (CAS 1228371-11-6) is a cosmetic cosmetic ingredient functioning as Skin conditioning — anti-aging; stimulates collagen I, III, IV synthesis;. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 1228371-11-6 →
Function
Skin conditioning — anti-aging; stimulates collagen I, III, IV synthesis; boosts laminin-5, integrins; strengthens dermal-epidermal junction (DEJ)
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
(2S)-5-amino-2-[[(2S)-1-[2-[[(2S)-5-amino-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoic acid
InChIKey
OGNHOGPWQTWKGQ-VGWMRTNUSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — not restricted under 21 CFR; no dedicated CIR review published
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexapeptide-9.
Calculate MoS for your specific formulation with the MoS Calculator.
Editorial summary
Preliminary editorial summary for Hexapeptide-9 — not a computed safety verdict. See the sourced toxicological data above.
Frequently Asked Questions
Is Hexapeptide-9 allowed in the EU?
Hexapeptide-9 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexapeptide-9 do in cosmetics?
Hexapeptide-9 functions as: Skin conditioning — anti-aging; stimulates collagen I, III, IV synthesis; boosts laminin-5, integrins; strengthens dermal-epidermal junction (DEJ). It is classified as a cosmetic ingredient in our database. CAS number: 1228371-11-6.
Compliance Tools
Check Hexapeptide-9 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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