Humulus lupulus Oil

INCI: HUMULUS LUPULUS OIL

CAS Number
8007-04-3
Function
Fragrance ingredient
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” GRAS under 21 CFR 182.20. CIR concluded safe as used when formulated to be non-sensitizing (2017)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Approximately 25% ฮฒ-myrcene content. NTP 2-year study showed clear evidence of carcinogenicity in male rats (kidney) and male mice (liver) at 1.0 g/kg/day oral; CIR Panel determined not relevant to human cosmetic exposure. Requires IFRA-compliant usage rates if used as fragrance and compositional certification per batch.

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Concern Level: High

Regulatory Flags

plant-oil fragrance-component ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Humulus lupulus Oil safe in cosmetics?

Approximately 25% ฮฒ-myrcene content. NTP 2-year study showed clear evidence of carcinogenicity in male rats (kidney) and male mice (liver) at 1.0 g/kg/day oral; CIR Panel determined not relevant to human cosmetic exposure. Requires IFRA-compliant usage rates if used as fragrance and compositional certification per batch. The EU classifies Humulus lupulus Oil as "permitted". Safety rating: MODERATE.

Is Humulus lupulus Oil allowed in the EU?

Humulus lupulus Oil EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Humulus lupulus Oil do in cosmetics?

Humulus lupulus Oil functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 8007-04-3.

What is the Margin of Safety for Humulus lupulus Oil?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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