Is Hyaluronidase safe in cosmetics?
Hyaluronidase has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Hyaluronidase
INCI: HYALURONIDASE
Hyaluronidase (CAS 9001-54-1 (bovine testicular origin)) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent (enzyme); also used in HA manufacturing to produce. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 9001-54-1 (bovine testicular origin) →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent (enzyme); also used in HA manufacturing to produce hydrolyzed forms
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted in cosmetics; also FDA-approved as injectable drug (Hylenex) for subcutaneous fluid administration
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hyaluronidase.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Hyaluronidase.
Frequently Asked Questions
Is Hyaluronidase allowed in the EU?
Hyaluronidase EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hyaluronidase do in cosmetics?
Hyaluronidase functions as: Skin conditioning agent (enzyme); also used in HA manufacturing to produce hydrolyzed forms. It is classified as a cosmetic ingredient in our database. CAS number: 9001-54-1 (bovine testicular origin).
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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