Hydrangea Macrophylla Root Extract

INCI: HYDRANGEA MACROPHYLLA ROOT EXTRACT

CAS Number
97722-03-7 (species-level CAS; root-specific CAS not separately assigned)
Function
Skin Conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no CFR restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Hydrangea macrophylla root extract contains higher levels of hydrangenol and umbelliferone than leaf tissue; traditional oral use at high doses associated with gastrointestinal effects; extraction solvent and standardization are critical for cosmetic product safety review.

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Concern Level: Moderate

Regulatory Flags

plant-extract

Frequently Asked Questions

Is Hydrangea Macrophylla Root Extract safe in cosmetics?

Hydrangea macrophylla root extract contains higher levels of hydrangenol and umbelliferone than leaf tissue; traditional oral use at high doses associated with gastrointestinal effects; extraction solvent and standardization are critical for cosmetic product safety review. The EU classifies Hydrangea Macrophylla Root Extract as "permitted". Safety rating: MODERATE.

Is Hydrangea Macrophylla Root Extract allowed in the EU?

Hydrangea Macrophylla Root Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydrangea Macrophylla Root Extract do in cosmetics?

Hydrangea Macrophylla Root Extract functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 97722-03-7 (species-level CAS; root-specific CAS not separately assigned).

What is the Margin of Safety for Hydrangea Macrophylla Root Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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