Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Isobutyl Methacrylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 120 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 300 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 1000 mg/kg bw/day | oral | - | oral | REACH |
Expert Verdict
Residual free monomer must be minimized (target <100 ppm in finished polymer); methacrylate allergy cross-reactivity risk; if used in nail products, additional SCCS scrutiny applies; specify copolymer form in CPSR Part A
Frequently Asked Questions
Is Isobutyl Methacrylate safe in cosmetics?
Residual free monomer must be minimized (target <100 ppm in finished polymer); methacrylate allergy cross-reactivity risk; if used in nail products, additional SCCS scrutiny applies; specify copolymer form in CPSR Part A The EU classifies Isobutyl Methacrylate as "permitted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.
Is Isobutyl Methacrylate allowed in the EU?
Isobutyl Methacrylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isobutyl Methacrylate do in cosmetics?
Isobutyl Methacrylate functions as: Film forming (typically used in copolymer form). It is classified as a cosmetic ingredient in our database. CAS number: 97-86-9.
What is the Margin of Safety for Isobutyl Methacrylate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Isobutyl Methacrylate?
The NOAEL (No Observed Adverse Effect Level) for Isobutyl Methacrylate is 120 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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