Is Isobutyl Methacrylate safe in cosmetics?
Isobutyl Methacrylate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Isobutyl Methacrylate
Also known as: 2-Propenoic acid, 2-methyl-, 2-methylpropyl ester, BRN 1747595, EINECS 202-613-0, Isobutyl alpha-methacrylate, Isobutyl alpha-methylacrylate (+7 more)
INCI: ISOBUTYL METHACRYLATE
Isobutyl Methacrylate (CAS 97-86-9) is a cosmetic cosmetic ingredient functioning as Film forming (typically used in copolymer form). NOAEL 120 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 97-86-9 →
Auto-generated CPSR Part A draft with source citations
Function
Film forming (typically used in copolymer form)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-methylpropyl 2-methylprop-2-enoate
InChIKey
RUMACXVDVNRZJZ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted, not listed under 21 CFR 700.11-700.35 prohibited substances
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isobutyl Methacrylate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Isobutyl Methacrylate across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
FlammableHarmful / Irritant
Hazard Class and Category
Flam. Liq. 3; STOT SE 3; Skin Irrit. 2; Skin Sens. 1B
Hazard Statements
- H226 Flammable liquid and vapour
- H335 May cause respiratory irritation
- H315 Causes skin irritation
- H317 May cause an allergic skin reaction
Inserted via ATP: ATP13
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
Irritating to ... respiratory system ... .
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Film former
Flavouring and nutrient
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Isobutyl Methacrylate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Isobutyl Methacrylate by CAS number or substance name.
Studies
21
Lowest NOAEL
30 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
2-Propenoic acid, 2-methyl-, 2-methylpropyl ester
BRN 1747595
EINECS 202-613-0
Isobutyl alpha-methacrylate
Isobutyl alpha-methylacrylate
Isobutyl 2-methyl-2-propenoate
2-Methylpropyl methacrylate
2-Methylpropyl 2-methyl-2-propenoate
NSC 18607
Propenoic acid, 2-methyl, isobutyl ester
Isobutylester kyseliny methakrylove
UNII-V11534UYZ0
Chemical Function
Film former
Flavouring and nutrient
Regulatory Lists
Europe
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1453087
Frequently Asked Questions
Is Isobutyl Methacrylate allowed in the EU?
Isobutyl Methacrylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isobutyl Methacrylate do in cosmetics?
Isobutyl Methacrylate functions as: Film forming (typically used in copolymer form). It is classified as a cosmetic ingredient in our database. CAS number: 97-86-9.
Is Isobutyl Methacrylate used outside cosmetics?
Isobutyl Methacrylate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Isobutyl Methacrylate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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