Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Isobutyltriethoxysilane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 0.56 other | 1991 | rat | inhalation | REACH |
| NOAEL | 50 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 4.4 other | 1991 | rat | inhalation | REACH |
| NOAEL | 50 mg/kg bw/day | oral | - | oral | REACH |
| NOEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 0.56 2100 | 1991 | rat | inhalation | REACH |
| NOAEL | 50 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 50 mg/kg bw/day | oral | - | oral | REACH |
| LOAEL | 2.2 2100 | inhalation | - | inhalation | REACH |
| NOAEL | 4.4 2100 | 1991 | rat | inhalation | REACH |
Expert Verdict
Organosilane compounds can be irritating in neat form; limited cosmetic-specific toxicological literature; the reacted/cured form on pigment surfaces is considered inert. Organosilane coupling agent; hydrolyzes to form silanol groups that bond to inorganic surfaces, creating a hydrophobic layer that improves pigment dispersibility in oil phases and enhances water resistance
Frequently Asked Questions
Is Isobutyltriethoxysilane safe in cosmetics?
Organosilane compounds can be irritating in neat form; limited cosmetic-specific toxicological literature; the reacted/cured form on pigment surfaces is considered inert. Organosilane coupling agent; hydrolyzes to form silanol groups that bond to inorganic surfaces, creating a hydrophobic layer that improves pigment dispersibility in oil phases and enhances water resistance The EU classifies Isobutyltriethoxysilane as "permitted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.
Is Isobutyltriethoxysilane allowed in the EU?
Isobutyltriethoxysilane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isobutyltriethoxysilane do in cosmetics?
Isobutyltriethoxysilane functions as: Surface treatment / binding agent (used to hydrophobically modify pigments and fillers in cosmetics). It is classified as a cosmetic ingredient in our database. CAS number: 17980-47-1.
What is the Margin of Safety for Isobutyltriethoxysilane?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Isobutyltriethoxysilane?
The NOAEL (No Observed Adverse Effect Level) for Isobutyltriethoxysilane is 0.56 other based on a inhalation study via 1991 route in rat. A total of 10 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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