Is Isobutyltriethoxysilane safe in cosmetics?
Isobutyltriethoxysilane has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Isobutyltriethoxysilane
Also known as: Silane, triethoxy(2-methylpropyl)-, (2-Methylpropyl)triethoxysilane, Silane, triethoxyisobutyl-, Triethoxy(2-methylpropyl)silane, Dynasylan IBTEO (+6 more)
INCI: ISOBUTYLTRIETHOXYSILANE
Isobutyltriethoxysilane (CAS 17980-47-1) is a cosmetic cosmetic ingredient functioning as Surface treatment / binding agent (used to hydrophobically modify pigments and. NOAEL 50 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 17980-47-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Isobutyltriethoxysilane is classified GHS Danger (H315, H314) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Surface treatment / binding agent (used to hydrophobically modify pigments and fillers in cosmetics)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
triethoxy(2-methylpropyl)silane
InChIKey
ALVYUZIFSCKIFP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed; no specific prohibition (silane-treated pigments are common in FDA-compliant color cosmetics)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isobutyltriethoxysilane.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Isobutyltriethoxysilane across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Skin Irrit. 2
Hazard Statements
- H315 Causes skin irritation
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Binder
Dispersing agent
Expert Verdict
Expert safety assessment and concern-level summary for Isobutyltriethoxysilane.
Known Synonyms
Silane, triethoxy(2-methylpropyl)-
(2-Methylpropyl)triethoxysilane
Silane, triethoxyisobutyl-
Triethoxy(2-methylpropyl)silane
Dynasylan IBTEO
Dynasylan BSM 100N
Dynasylan BSM 40N
Z 6403
Triethoxyisobutylsilane
Sicong SP 205
Xiameter OFS 6403
Chemical Function
Binder
Dispersing agent
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3186627
Frequently Asked Questions
Is Isobutyltriethoxysilane allowed in the EU?
Isobutyltriethoxysilane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isobutyltriethoxysilane do in cosmetics?
Isobutyltriethoxysilane functions as: Surface treatment / binding agent (used to hydrophobically modify pigments and fillers in cosmetics). It is classified as a cosmetic ingredient in our database. CAS number: 17980-47-1.
Is Isobutyltriethoxysilane used outside cosmetics?
Isobutyltriethoxysilane also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Isobutyltriethoxysilane have different safety status in cosmetics vs industrial chemicals?
Isobutyltriethoxysilane is classified GHS Danger (H315, H314) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Isobutyltriethoxysilane compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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