Is Hexadecyl Methicone safe in cosmetics?
Hexadecyl Methicone has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Hexadecyl Methicone
Also known as: Silane, triethoxy(2-methylpropyl)-, (2-Methylpropyl)triethoxysilane, Silane, triethoxyisobutyl-, Triethoxy(2-methylpropyl)silane, Isobutyltriethoxysilane (+7 more)
Hexadecyl Methicone (CAS 17980-47-1) is a cosmetic cosmetic ingredient functioning as Softener and conditioner; Viscosity modifier. NOAEL 50 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 17980-47-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Hexadecyl Methicone is classified GHS Danger (H315, H314) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Softener and conditioner; Viscosity modifier
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
triethoxy(2-methylpropyl)silane
InChIKey
ALVYUZIFSCKIFP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — covered under CIR assessment of Methicone family
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexadecyl Methicone.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Hexadecyl Methicone across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Skin Irrit. 2
Hazard Statements
- H315 Causes skin irritation
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Binder
Dispersing agent
Expert Verdict
Expert safety assessment and concern-level summary for Hexadecyl Methicone.
Known Synonyms
Silane, triethoxy(2-methylpropyl)-
(2-Methylpropyl)triethoxysilane
Silane, triethoxyisobutyl-
Triethoxy(2-methylpropyl)silane
Isobutyltriethoxysilane
Dynasylan IBTEO
Dynasylan BSM 100N
Dynasylan BSM 40N
Z 6403
Triethoxyisobutylsilane
Sicong SP 205
Xiameter OFS 6403
Chemical Function
Binder
Dispersing agent
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3186627
Frequently Asked Questions
Is Hexadecyl Methicone allowed in the EU?
Hexadecyl Methicone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexadecyl Methicone do in cosmetics?
Hexadecyl Methicone functions as: Softener and conditioner; Viscosity modifier. It is classified as a cosmetic ingredient in our database. CAS number: 17980-47-1.
Is Hexadecyl Methicone used outside cosmetics?
Hexadecyl Methicone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Hexadecyl Methicone have different safety status in cosmetics vs industrial chemicals?
Hexadecyl Methicone is classified GHS Danger (H315, H314) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Hexadecyl Methicone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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