Excellent Cosmetic Ingredient NOAEL Data

Hexadecyl Methicone

CAS Number

17980-47-1

Function

Softener and conditioner; Viscosity modifier

Safety Rating

EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted

🇺🇸 US Status permitted

US Notes Permitted — covered under CIR assessment of Methicone family

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)

adequate

Dermal Absorption

negligible

Sensitization

none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Hexadecyl Methicone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	0.56 other	1991	rat	inhalation	REACH
NOAEL	50 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	4.4 other	1991	rat	inhalation	REACH
NOAEL	50 mg/kg bw/day	oral	-	oral	REACH
NOEL	1000 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	0.56 2100	1991	rat	inhalation	REACH
NOAEL	50 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	50 mg/kg bw/day	oral	-	oral	REACH
LOAEL	2.2 2100	inhalation	-	inhalation	REACH
NOAEL	4.4 2100	1991	rat	inhalation	REACH

Expert Verdict

⚠️

Concern Level: Low

Frequently Asked Questions

Is Hexadecyl Methicone safe in cosmetics?

CIR review covers the methicone family including alkyl methicones. Inhalation caution in spray/aerosol products. Ensure low-MW cyclic siloxane impurities (D4, D5, D6) comply with EU limits per Annex II entry 1639 (Regulation 2018/35). The EU classifies Hexadecyl Methicone as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.

Is Hexadecyl Methicone allowed in the EU?

Hexadecyl Methicone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hexadecyl Methicone do in cosmetics?

Hexadecyl Methicone functions as: Softener and conditioner; Viscosity modifier. It is classified as a cosmetic ingredient in our database. CAS number: 17980-47-1.

What is the Margin of Safety for Hexadecyl Methicone?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Hexadecyl Methicone?

The NOAEL (No Observed Adverse Effect Level) for Hexadecyl Methicone is 0.56 other based on a inhalation study via 1991 route in rat. A total of 10 study endpoints are available. Source: REACH.

Compliance Tools

Check Hexadecyl Methicone compliance across multiple jurisdictions:

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Ingredient Decoder

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82 Allergen Checker

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Substance Compliance

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MoS Calculator

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Heavy Metal Limits

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