Isopropyl Phenylacetaldehyde
INCI: ISOPROPYL PHENYLACETALDEHYDE (ALSO LISTED AS AR-ISOPROPYLPHENYLACETALDEHYDE)
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Isopropyl Phenylacetaldehyde. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 19 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 19 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
RIFM safety assessment identifies it as a potential skin sensitizer (NESIL 1100 µg/cm²); Cramer Class I toxicity; not expected to be genotoxic or photoirritating/photoallergenic based on UV/Vis spectra and read-across data. Subchronic reference dose of 0.045 mg/kg/day; predicted dermal absorption of 80%; subject to Quantitative Risk Assessment (QRA2) for IFRA compliance
Regulatory Flags
Frequently Asked Questions
Is Isopropyl Phenylacetaldehyde safe in cosmetics?
RIFM safety assessment identifies it as a potential skin sensitizer (NESIL 1100 µg/cm²); Cramer Class I toxicity; not expected to be genotoxic or photoirritating/photoallergenic based on UV/Vis spectra and read-across data. Subchronic reference dose of 0.045 mg/kg/day; predicted dermal absorption of 80%; subject to Quantitative Risk Assessment (QRA2) for IFRA compliance The EU classifies Isopropyl Phenylacetaldehyde as "restricted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.
Is Isopropyl Phenylacetaldehyde allowed in the EU?
Isopropyl Phenylacetaldehyde EU regulatory status: restricted. Maximum allowed concentration: 0.004%. This is based on EU Regulation 1223/2009 and its amendments.
What does Isopropyl Phenylacetaldehyde do in cosmetics?
Isopropyl Phenylacetaldehyde functions as: Fragrance (perfuming agent); declared as "PARFUM" on product labels. It is classified as a cosmetic ingredient in our database. CAS number: 4395-92-0.
What is the Margin of Safety for Isopropyl Phenylacetaldehyde?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Isopropyl Phenylacetaldehyde?
The NOAEL (No Observed Adverse Effect Level) for Isopropyl Phenylacetaldehyde is 19 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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