Is ISOPROPYLIDENEDIPHENYL BISOXYHYDROXYPROPYL METHACRYLATE safe in cosmetics?
ISOPROPYLIDENEDIPHENYL BISOXYHYDROXYPROPYL METHACRYLATE has a safety rating of "GOOD" in our database. EU status: permitted.
Good
Cosmetic Ingredient
ISOPROPYLIDENEDIPHENYL BISOXYHYDROXYPROPYL METHACRYLATE
Also known as: Bisphenol A-glycidyl methacrylate (2-Propenoic acid, 2-methyl-, (1-methylethylidene)bis[4,1-phenyleneoxy(2-hydroxy-3,1-propanediyl)] ester), Bisphenol A-diglycidyl-dimethyl acrylate, Bisphenol(a)glycidylmethacrylate, BRN 2316426, EINECS 216-367-7 (+11 more)
ISOPROPYLIDENEDIPHENYL BISOXYHYDROXYPROPYL METHACRYLATE (CAS 1565-94-2) is a cosmetic cosmetic ingredient functioning as Film Forming. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 1565-94-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
ISOPROPYLIDENEDIPHENYL BISOXYHYDROXYPROPYL METHACRYLATE is classified GHS Danger (H315, H317, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Film Forming
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
[2-hydroxy-3-[4-[2-[4-[2-hydroxy-3-(2-methylprop-2-enoyloxy)propoxy]phenyl]propan-2-yl]phenoxy]propyl] 2-methylprop-2-enoate
InChIKey
AMFGWXWBFGVCKG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
KeratinoSens IC50
22.804 µM
LLNA EC3
45%
NESIL
11250 µg/cm²
LLNA: Weak (1B)
GHS: 1B
Source: LLNA: Kern et al. (2010); KS: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008]
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Film former
Monomers
Expert Verdict
Expert safety assessment and concern-level summary for ISOPROPYLIDENEDIPHENYL BISOXYHYDROXYPROPYL METHACRYLATE.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
Known Synonyms
Bisphenol A-glycidyl methacrylate (2-Propenoic acid, 2-methyl-, (1-methylethylidene)bis[4,1-phenyleneoxy(2-hydroxy-3,1-propanediyl)] ester)
Bisphenol A-diglycidyl-dimethyl acrylate
Bisphenol(a)glycidylmethacrylate
BRN 2316426
EINECS 216-367-7
Bis(Phenol A-Glycidyl Methacrylate), Homopolymer
Bis-GMA Polymer
Poly(Bis-GMA)
Retroplast
NuvaSeal
Panavia Opaque
Enamel Bond, Concise
Concise Enamel Bond
Epoxylite 9075
UNII-454I75YXY0
2,2-Bis[4-(2-hydroxy-3-methacryloxypropoxy)phenyl]propane
Chemical Function
Film former
Monomers
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1600257
Frequently Asked Questions
Is ISOPROPYLIDENEDIPHENYL BISOXYHYDROXYPROPYL METHACRYLATE allowed in the EU?
ISOPROPYLIDENEDIPHENYL BISOXYHYDROXYPROPYL METHACRYLATE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does ISOPROPYLIDENEDIPHENYL BISOXYHYDROXYPROPYL METHACRYLATE do in cosmetics?
ISOPROPYLIDENEDIPHENYL BISOXYHYDROXYPROPYL METHACRYLATE functions as: Film Forming. It is classified as a cosmetic ingredient in our database. CAS number: 1565-94-2.
Is ISOPROPYLIDENEDIPHENYL BISOXYHYDROXYPROPYL METHACRYLATE used outside cosmetics?
ISOPROPYLIDENEDIPHENYL BISOXYHYDROXYPROPYL METHACRYLATE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does ISOPROPYLIDENEDIPHENYL BISOXYHYDROXYPROPYL METHACRYLATE have different safety status in cosmetics vs industrial chemicals?
ISOPROPYLIDENEDIPHENYL BISOXYHYDROXYPROPYL METHACRYLATE is classified GHS Danger (H315, H317, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
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Substance Compliance
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MoS Calculator
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