Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Isotretinoin has a good safety profile and is generally considered safe for cosmetic use.
Frequently Asked Questions
Is Isotretinoin safe in cosmetics?
Isotretinoin has a good safety profile and is generally considered safe for cosmetic use. The EU classifies Isotretinoin as "permitted". Safety rating: GOOD.
Is Isotretinoin allowed in the EU?
Isotretinoin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isotretinoin do in cosmetics?
Isotretinoin functions as: Insufficient Data. It is classified as a Cosmetic Ingredient in our database. CAS number: None.
What is the Margin of Safety for Isotretinoin?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check Isotretinoin compliance across multiple jurisdictions:
Related Ingredients
Is Isotretinoin in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Isotretinoin in your formulation.