Dicaprylyl Ether

INCI: DICAPRYLYL ETHER

CAS Number
None
Function
Emollient
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No FDA-specific restrictions. Not an FDA-listed sunscreen active; not evaluated as a GRASE UV filter. Registered in FDA VCRP with 239 formulations (2021 data). Subject only to general cosmetic safety requirements under the FD&C Act.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Dicaprylyl Ether (CAS 629-82-3) is a fatty dialkyl ether emollient permitted without restriction in the EU under Regulation 1223/2009, with industry-reported use levels up to 25% in leave-on products. The CIR Expert Panel concluded it is safe in cosmetics at present practices of use and concentration, supported by a NOAEL โ‰ฅ 1000 mg/kg bw/day, very low dermal absorption of 0.3%, and an MoS exceeding 10,000 even in worst-case scenarios. Genotoxicity is negative across Ames, chromosome aberration, and mouse lymphoma assays; the ingredient is non-sensitizing in animal and human tests at cosmetic-relevant concentrations.

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Concern Level: None

Regulatory Flags

eu-unrestricted cir-approved no-sccs-opinion

Frequently Asked Questions

Is Dicaprylyl Ether safe in cosmetics?

Dicaprylyl Ether (CAS 629-82-3) is a fatty dialkyl ether emollient permitted without restriction in the EU under Regulation 1223/2009, with industry-reported use levels up to 25% in leave-on products. The CIR Expert Panel concluded it is safe in cosmetics at present practices of use and concentration, supported by a NOAEL โ‰ฅ 1000 mg/kg bw/day, very low dermal absorption of 0.3%, and an MoS exceeding 10,000 even in worst-case scenarios. Genotoxicity is negative across Ames, chromosome aberration, and mouse lymphoma assays; the ingredient is non-sensitizing in animal and human tests at cosmetic-relevant concentrations. The EU classifies Dicaprylyl Ether as "permitted". Safety rating: EXCELLENT.

Is Dicaprylyl Ether allowed in the EU?

Dicaprylyl Ether EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dicaprylyl Ether do in cosmetics?

Dicaprylyl Ether functions as: Emollient. It is classified as a Cosmetic Ingredient in our database. CAS number: None.

What is the Margin of Safety for Dicaprylyl Ether?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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