Regulatory Status
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Safety Data
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Expert Verdict
Kallikrein is a serine protease enzyme. Overactivity of kallikrein-related peptidases (KLK5, KLK7) in the skin is implicated in rosacea, psoriasis, and impaired barrier function. Formulators must ensure controlled enzymatic activity to avoid disruption of the skin barrier or excessive cathelicidin processing. Not recommended for compromised or sensitized skin.. Kallikrein enzymes play a critical role in skin desquamation by hydrolyzing corneodesmosomes and processing profilaggrin. In cosmetic...
Regulatory Flags
Frequently Asked Questions
Is Kallikrein safe in cosmetics?
Kallikrein is a serine protease enzyme. Overactivity of kallikrein-related peptidases (KLK5, KLK7) in the skin is implicated in rosacea, psoriasis, and impaired barrier function. Formulators must ensure controlled enzymatic activity to avoid disruption of the skin barrier or excessive cathelicidin processing. Not recommended for compromised or sensitized skin.. Kallikrein enzymes play a critical role in skin desquamation by hydrolyzing corneodesmosomes and processing profilaggrin. In cosmetic... The EU classifies Kallikrein as "permitted". Safety rating: MODERATE.
Is Kallikrein allowed in the EU?
Kallikrein EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Kallikrein do in cosmetics?
Kallikrein functions as: Enzyme, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 9001-01-8 (tissue kallikrein / pancreatic kallikrein).
What is the Margin of Safety for Kallikrein?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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