Is Ketoglutaric Acid safe in cosmetics?
Ketoglutaric Acid has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Ketoglutaric Acid
Also known as: Alphaketoglutaric acid, EINECS 206-330-3, Glutaric acid, alpha keto, alpha-Oxoglutaric acid, Bis(L-arginin)-2-oxoglutarat (+8 more)
INCI: KETOGLUTARIC ACID
Ketoglutaric Acid (CAS 328-50-7) is a cosmetic cosmetic ingredient functioning as Skin conditioning / buffering agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 328-50-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Ketoglutaric Acid is classified GHS Danger (H315, H318, H335) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin conditioning / buffering agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-oxopentanedioic acid
InChIKey
KPGXRSRHYNQIFN-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no CFR restriction; GRAS for food use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ketoglutaric Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (5)
JECFA Number
634
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-KETOGLUTARIC ACID | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/67 | FAS 44-JECFA 53/229
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
alpha-KETOGLUTARIC ACID | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/67 | FAS 44-JECFA 53/229
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-OXOGLUTARIC ACID | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/67 | FAS 44-JECFA 53/229
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-OXOPENTANEDIOIC ACID | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/67 | FAS 44-JECFA 53/229
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Ketoglutaric Acid.
Regulatory Flags
fda_food_additive
Known Synonyms
Alphaketoglutaric acid
EINECS 206-330-3
Glutaric acid, alpha keto
alpha-Oxoglutaric acid
Bis(L-arginin)-2-oxoglutarat
alpha Ketoglutarate
UNII-8ID597Z82X
alpha-Ketoglutaricum acidum
2-Ketoglutarate
2-Oxo-1,5-pentanedioate
2-Oxoglutarate
2-Oxopentanedioate
Oxoglutarate
Chemical Function
Deodorizer
Flavouring and nutrient
Regulatory Lists
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ALPHA-KETOGLUTARIC ACID
ChEMBL ID
CHEMBL1686
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
2-OXOPENTANEDIOIC ACID
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Ketoglutaric Acid allowed in the EU?
Ketoglutaric Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ketoglutaric Acid do in cosmetics?
Ketoglutaric Acid functions as: Skin conditioning / buffering agent. It is classified as a cosmetic ingredient in our database. CAS number: 328-50-7.
Is Ketoglutaric Acid used outside cosmetics?
Ketoglutaric Acid also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Ketoglutaric Acid have different safety status in cosmetics vs industrial chemicals?
Ketoglutaric Acid is classified GHS Danger (H315, H318, H335) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Ketoglutaric Acid compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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