Ketoglutaric Acid

INCI: KETOGLUTARIC ACID

CAS Number
328-50-7
Function
Skin conditioning / buffering agent
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no CFR restriction; GRAS for food use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

H318 classification indicates serious eye damage risk; irritation is pH-dependent and concentration-dependent; must be buffered or neutralized in finished product; no mutagenicity or carcinogenicity concerns.

โš ๏ธ
Concern Level: High

Regulatory Flags

fda_food_additive

Frequently Asked Questions

Is Ketoglutaric Acid safe in cosmetics?

H318 classification indicates serious eye damage risk; irritation is pH-dependent and concentration-dependent; must be buffered or neutralized in finished product; no mutagenicity or carcinogenicity concerns. The EU classifies Ketoglutaric Acid as "permitted". Safety rating: MODERATE.

Is Ketoglutaric Acid allowed in the EU?

Ketoglutaric Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ketoglutaric Acid do in cosmetics?

Ketoglutaric Acid functions as: Skin conditioning / buffering agent. It is classified as a cosmetic ingredient in our database. CAS number: 328-50-7.

What is the Margin of Safety for Ketoglutaric Acid?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is Ketoglutaric Acid in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Ketoglutaric Acid in your formulation.