Good Cosmetic Ingredient NOAEL Data

Lactamide MEA

INCI: LACTAMIDE MEA

CAS Number
142-78-9
Function
Humectant, skin conditioning
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” CIR Expert Panel found ethanolamides safe as used when formulated to be non-irritating

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Lactamide MEA. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=1000 mg/kg bw/day oral rat oral REACH

Expert Verdict

MEA impurities should be controlled; lower nitrosamine risk than DEA amides but contamination monitoring advised; no mutagenicity reported in analogous MEA amides

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Concern Level: Low

Frequently Asked Questions

Is Lactamide MEA safe in cosmetics?

MEA impurities should be controlled; lower nitrosamine risk than DEA amides but contamination monitoring advised; no mutagenicity reported in analogous MEA amides The EU classifies Lactamide MEA as "restricted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is Lactamide MEA allowed in the EU?

Lactamide MEA EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Lactamide MEA do in cosmetics?

Lactamide MEA functions as: Humectant, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 142-78-9.

What is the Margin of Safety for Lactamide MEA?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Lactamide MEA?

The NOAEL (No Observed Adverse Effect Level) for Lactamide MEA is >=1000 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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