Is Allyl Heptanoate safe in cosmetics?
Allyl Heptanoate has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted.
Good
Cosmetic Ingredient
Allyl Heptanoate
Also known as: Heptanoic acid, 2-propenyl ester, Heptanoic acid, 2-propen-1-yl ester, Allyl enanthate, Allyl heptoate, Allyl heptylate (+6 more)
INCI: ALLYL HEPTANOATE
Allyl Heptanoate (CAS 142-19-8) is a cosmetic cosmetic ingredient functioning as Fragrance (perfuming agent). NOAEL 30 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 142-19-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Allyl Heptanoate is classified GHS Danger (H301, H302, H312, H311, H315, H319, H373, H400) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance (perfuming agent)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
prop-2-enyl heptanoate
InChIKey
SJWKGDGUQTWDRV-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted in cosmetics; FEMA GRAS for flavoring
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Allyl Heptanoate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Allyl Heptanoate across SCCS product categories, with measured dermal absorption where available.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
1350 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [86] Kligman AM (1975): Report to RIFM, 10 June, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 1350 | - | - |
| HMT | - | 0 | 2592 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
BRIN Brazil/India Cosmetics
India: Restricted
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Regulatory (2)
JECFA Number
4
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ALLYL OENANTHATE | 1996 | 0-0.15 mg/kg bw (1990) | No safety concern at current levels of intake when used as a flavouring agent. The 1990 ADI, equivalent to 0-0.05 mg/kg allyl alcohol, for allyl heptanoate, allyl hexanoate and allyl isovalerate, was maintained at the forty-sixth meeting (1996). | TRS 868-JECFA 46/28
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (4)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Allyl Heptanoate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
eu_cosing_listed
Known Synonyms
Heptanoic acid, 2-propenyl ester
Heptanoic acid, 2-propen-1-yl ester
Allyl enanthate
Allyl heptoate
Allyl heptylate
EINECS 205-527-1
FEMA No. 2031
NSC 20969
2-Propenyl heptanoate
Allylester kyseliny enanthove
UNII-AU4CYG9V68
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
air; detected; emissions; Europe; Vehicle - car interior
air; detected; emissions; Europe; Vehicle - car interior
detected; Europe; Vehicle - car interior
air; detected; emissions; Personal care
air; Cleaning products and household care - air freshener; detected; emissions
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ALLYL HEPTANOATE
ChEMBL ID
CHEMBL2268885
Frequently Asked Questions
Is Allyl Heptanoate allowed in the EU?
Allyl Heptanoate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Allyl Heptanoate do in cosmetics?
Allyl Heptanoate functions as: Fragrance (perfuming agent). It is classified as a cosmetic ingredient in our database. CAS number: 142-19-8.
Is Allyl Heptanoate used outside cosmetics?
Allyl Heptanoate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Allyl Heptanoate have different safety status in cosmetics vs industrial chemicals?
Allyl Heptanoate is classified GHS Danger (H301, H302, H312, H311, H315, H319, H373, H400) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Allyl Heptanoate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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