Good Cosmetic Ingredient NOAEL Data

Allyl Heptanoate

INCI: ALLYL HEPTANOATE

CAS Number
142-19-8
Function
Fragrance (perfuming agent)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted in cosmetics; FEMA GRAS for flavoring

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Allyl Heptanoate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 5 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 75 mg/kg bw/day oral dog Chronic COSMOS_DB
NOAEL 100 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 75 mg/kg bw/day oral dog Chronic COSMOS_DB
NOAEL 25 mg/kg bw/day oral dog Chronic COSMOS_DB
NOAEL 49.6 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 5 mg/kg bw/day oral dog Chronic COSMOS_DB
LOAEL 25 mg/kg bw/day oral dog Chronic COSMOS_DB
LOAEL 49.5999984741 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 30 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB

Expert Verdict

IFRA standard concentration limits apply; raw material handling precautions needed (allyl ester class); free allyl alcohol specification

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Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive eu_cosing_listed

Frequently Asked Questions

Is Allyl Heptanoate safe in cosmetics?

IFRA standard concentration limits apply; raw material handling precautions needed (allyl ester class); free allyl alcohol specification The EU classifies Allyl Heptanoate as "restricted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is Allyl Heptanoate allowed in the EU?

Allyl Heptanoate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Allyl Heptanoate do in cosmetics?

Allyl Heptanoate functions as: Fragrance (perfuming agent). It is classified as a cosmetic ingredient in our database. CAS number: 142-19-8.

What is the Margin of Safety for Allyl Heptanoate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Allyl Heptanoate?

The NOAEL (No Observed Adverse Effect Level) for Allyl Heptanoate is 5 mg/kg bw/day based on a Carcinogenicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

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