Is Madrox safe in cosmetics?
Madrox has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Madrox
Also known as: BRN 2238172, EINECS 253-534-3, 1-Methylcyclododecyl methyl ether, 1-Methyl-1-methoxycyclododecane
INCI: MADROX (TRADE NAME BY GIVAUDAN; CHEMICAL NAME: 2,2,5-TRIMETHYL-5-PENTYLCYCLOPENTANONE)
Madrox (CAS 37514-30-0) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 37514-30-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Madrox is prohibited in EU cosmetics but has active industrial GHS classifications (H319).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance ingredient
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1-methoxy-1-methylcyclododecane
InChIKey
QACBYNLZEUNZSC-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Allowed - fragrance ingredients are permitted under manufacturer safety responsibility
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Madrox.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 13500 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for Madrox.
Regulatory Flags
fragrance-component
ifra_fragrance
Known Synonyms
BRN 2238172
EINECS 253-534-3
1-Methylcyclododecyl methyl ether
1-Methyl-1-methoxycyclododecane
Chemical Function
Fragrance
Regulatory Lists
IFRA Transparency
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Madrox allowed in the EU?
Madrox EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Madrox do in cosmetics?
Madrox functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 37514-30-0.
Is Madrox used outside cosmetics?
Madrox also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Madrox have different safety status in cosmetics vs industrial chemicals?
Madrox is prohibited in EU cosmetics but has active industrial GHS classifications (H319).
Compliance Tools
Check Madrox compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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