Is Manganese Gluconate safe in cosmetics?
Manganese Gluconate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
MODERATE
Cosmetic Ingredient
Manganese Gluconate
INCI: MANGANESE GLUCONATE
Manganese Gluconate (CAS 6485-39-8) is a cosmetic cosmetic ingredient functioning as Skin conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
Cross-Vertical Regulatory Divergence
Manganese Gluconate is classified GHS Danger (H302, H318, H372, H319) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Skin conditioning
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
manganese(2+);bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate)
InChIKey
OXHQNTSSPHKCPB-IYEMJOQQSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed in cosmetics; also GRAS as a food-grade nutrient (USP/FCC standard)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Manganese Gluconate.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Flavouring and nutrient
No specific technical function
Softener and conditioner
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Editorial summary
Preliminary editorial summary for Manganese Gluconate — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
potential-allergen
fda_food_additive
Chemical Function
Softener and conditioner
No specific technical function
Biocide
Flavouring and nutrient
Regulatory Lists
active_ingredient; animal_products; Europe; pharmaceutical; residue
Europe; supplements
Europe; food_additive; supplements
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
MANGANESE GLUCONATE
Food Category
flavoring
Frequently Asked Questions
Is Manganese Gluconate allowed in the EU?
Manganese Gluconate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Manganese Gluconate do in cosmetics?
Manganese Gluconate functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 6485-39-8.
Is Manganese Gluconate used outside cosmetics?
Manganese Gluconate also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Manganese Gluconate have different safety status in cosmetics vs industrial chemicals?
Manganese Gluconate is classified GHS Danger (H302, H318, H372, H319) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Manganese Gluconate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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