Melia Azadirachta (Neem) Leaf

INCI: MELIA AZADIRACHTA LEAF

CAS Number
84696-25-3 (general neem extract CAS may be cited; leaf-specific CAS not separately assigned)
Function
Skin conditioning (whole/powdered botanical)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no specific restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

CLP ATP 18 classification targets Azadirachta broadly; leaf contains lower azadirachtin than seed-derived materials but regulatory authorities may apply precautionary interpretation. Compositional analysis differentiating leaf from seed extract is essential before EU placement.

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Concern Level: Moderate

Frequently Asked Questions

Is Melia Azadirachta (Neem) Leaf safe in cosmetics?

CLP ATP 18 classification targets Azadirachta broadly; leaf contains lower azadirachtin than seed-derived materials but regulatory authorities may apply precautionary interpretation. Compositional analysis differentiating leaf from seed extract is essential before EU placement. The EU classifies Melia Azadirachta (Neem) Leaf as "permitted". Safety rating: MODERATE.

Is Melia Azadirachta (Neem) Leaf allowed in the EU?

Melia Azadirachta (Neem) Leaf EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Melia Azadirachta (Neem) Leaf do in cosmetics?

Melia Azadirachta (Neem) Leaf functions as: Skin conditioning (whole/powdered botanical). It is classified as a cosmetic ingredient in our database. CAS number: 84696-25-3 (general neem extract CAS may be cited; leaf-specific CAS not separately assigned).

What is the Margin of Safety for Melia Azadirachta (Neem) Leaf?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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