Moderate Cosmetic Ingredient NOAEL Data

Mentha Spicata Flower/Leaf/Stem Extract

INCI: MENTHA SPICATA FLOWER/LEAF/STEM EXTRACT

CAS Number
84696-51-5
Function
Fragrance (perfuming)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed. No specific prohibition or restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Mentha Spicata Flower/Leaf/Stem Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 93 mg/kg bw/day oral rat oral REACH
NOAEL 93 mg/kg bw/day oral - oral REACH
LOAEL 30 mg/kg bw/day oral rat oral REACH
LOAEL 30 mg/kg bw/day oral - oral REACH
NOAEL 93 mg/kg bw/day oral rat oral REACH
NOAEL 93 mg/kg bw/day oral - oral REACH
LOAEL 30 mg/kg bw/day oral rat oral REACH
LOAEL 30 mg/kg bw/day oral - oral REACH
LOAEL 750 mg/kg bw/day oral mouse oral REACH
LOAEL 750 mg/kg bw/day oral - oral REACH

Expert Verdict

Potential fragrance allergen sensitization. May cause irritation in sensitive skin at high concentrations. Solvent extract from the flowers, leaves, and stems of spearmint. Uses a broader plant-part profile than leaf-only extracts, capturing a wider phytochemical spectrum

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Concern Level: Moderate

Regulatory Flags

plant-extract potential-allergen fragrance-component fda_food_additive

Frequently Asked Questions

Is Mentha Spicata Flower/Leaf/Stem Extract safe in cosmetics?

Potential fragrance allergen sensitization. May cause irritation in sensitive skin at high concentrations. Solvent extract from the flowers, leaves, and stems of spearmint. Uses a broader plant-part profile than leaf-only extracts, capturing a wider phytochemical spectrum The EU classifies Mentha Spicata Flower/Leaf/Stem Extract as "permitted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.

Is Mentha Spicata Flower/Leaf/Stem Extract allowed in the EU?

Mentha Spicata Flower/Leaf/Stem Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Mentha Spicata Flower/Leaf/Stem Extract do in cosmetics?

Mentha Spicata Flower/Leaf/Stem Extract functions as: Fragrance (perfuming). It is classified as a cosmetic ingredient in our database. CAS number: 84696-51-5.

What is the Margin of Safety for Mentha Spicata Flower/Leaf/Stem Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Mentha Spicata Flower/Leaf/Stem Extract?

The NOAEL (No Observed Adverse Effect Level) for Mentha Spicata Flower/Leaf/Stem Extract is 93 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.

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