Moderate Cosmetic Ingredient

Menthyl Isovalerate

INCI: MENTHYL ISOVALERATE

CAS Number
16409-46-4
Function
Fragrance
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Allowed - used as a flavoring/fragrance agent; not prohibited or restricted

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

RIFM safety assessment concluded no genotoxicity, no reproductive toxicity, no skin sensitization, and no phototoxicity/photoallergenicity concerns; read-across from menthyl acetate supports safety profile. Fruity-type odor and flavor; classified under JECFA fragrance group; naturally occurring ester; typical use levels 0.2-3% depending on product type

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Concern Level: High

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Menthyl Isovalerate safe in cosmetics?

RIFM safety assessment concluded no genotoxicity, no reproductive toxicity, no skin sensitization, and no phototoxicity/photoallergenicity concerns; read-across from menthyl acetate supports safety profile. Fruity-type odor and flavor; classified under JECFA fragrance group; naturally occurring ester; typical use levels 0.2-3% depending on product type The EU classifies Menthyl Isovalerate as "permitted". Safety rating: MODERATE.

Is Menthyl Isovalerate allowed in the EU?

Menthyl Isovalerate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Menthyl Isovalerate do in cosmetics?

Menthyl Isovalerate functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 16409-46-4.

What is the Margin of Safety for Menthyl Isovalerate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Menthyl Isovalerate compliance across multiple jurisdictions:

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Ingredient Decoder
Paste a full ingredient list for instant analysis
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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