Menthyl Nicotinate

INCI: MENTHYL NICOTINATE

CAS Number
40594-50-9 (menthol ester of nicotinic acid - distinct from methyl nicotinate CAS 93-60-7)
Function
Rubefacient, vasodilator, skin conditioning agent
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed - not prohibited or restricted for cosmetic use; the related methyl nicotinate is used in OTC topical analgesics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Causes localized erythema (skin reddening) through vasodilation - this is the intended mechanism, but it can cause discomfort or adverse reactions in sensitive individuals; concentration must be carefully controlled. Induces peripheral vasodilation and transient increase in skin perfusion; produces a noticeable warming sensation on application; the menthyl ester form provides modified release kinetics compared to methyl nicotinate

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Concern Level: Moderate

Frequently Asked Questions

Is Menthyl Nicotinate safe in cosmetics?

Causes localized erythema (skin reddening) through vasodilation - this is the intended mechanism, but it can cause discomfort or adverse reactions in sensitive individuals; concentration must be carefully controlled. Induces peripheral vasodilation and transient increase in skin perfusion; produces a noticeable warming sensation on application; the menthyl ester form provides modified release kinetics compared to methyl nicotinate The EU classifies Menthyl Nicotinate as "restricted". Safety rating: MODERATE.

Is Menthyl Nicotinate allowed in the EU?

Menthyl Nicotinate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Menthyl Nicotinate do in cosmetics?

Menthyl Nicotinate functions as: Rubefacient, vasodilator, skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 40594-50-9 (menthol ester of nicotinic acid - distinct from methyl nicotinate CAS 93-60-7).

What is the Margin of Safety for Menthyl Nicotinate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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