Mercaptopropionic Acid

INCI: MERCAPTOPROPIONIC ACID

CAS Number
107-96-0 (3-mercaptopropionic acid)
Function
Depilatory agent, hair waving/straightening agent, reducing agent (breaks keratin disulfide bonds)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
EU Max Conc. 5%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed with labeling requirements; depilatory and wave products containing mercapto acids must bear appropriate caution statements.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Strong skin and eye irritant; highly alkaline formulations amplify irritation risk; characteristic strong sulfurous odor; potential sensitizer - though RIFM assessment found it not genotoxic and below the dermal sensitization threshold at declared use levels.. Thiol reducing agent; chemically analogous to thioglycolic acid; cleaves disulfide bonds in keratin for hair reshaping; must be formulated at controlled pH (typically 7-9.5 for general use, up to 12.7 for professional depilatory use).

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Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Mercaptopropionic Acid safe in cosmetics?

Strong skin and eye irritant; highly alkaline formulations amplify irritation risk; characteristic strong sulfurous odor; potential sensitizer - though RIFM assessment found it not genotoxic and below the dermal sensitization threshold at declared use levels.. Thiol reducing agent; chemically analogous to thioglycolic acid; cleaves disulfide bonds in keratin for hair reshaping; must be formulated at controlled pH (typically 7-9.5 for general use, up to 12.7 for professional depilatory use). The EU classifies Mercaptopropionic Acid as "restricted". Safety rating: MODERATE.

Is Mercaptopropionic Acid allowed in the EU?

Mercaptopropionic Acid EU regulatory status: restricted. Maximum allowed concentration: 5%. This is based on EU Regulation 1223/2009 and its amendments.

What does Mercaptopropionic Acid do in cosmetics?

Mercaptopropionic Acid functions as: Depilatory agent, hair waving/straightening agent, reducing agent (breaks keratin disulfide bonds). It is classified as a cosmetic ingredient in our database. CAS number: 107-96-0 (3-mercaptopropionic acid).

What is the Margin of Safety for Mercaptopropionic Acid?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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