Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Beta-Alanine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 3000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 3000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 3000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
Expert Verdict
Very low toxicity profile; naturally occurring amino acid; may cause transient paresthesia (tingling) at high oral doses but this is not relevant at typical cosmetic use levels. A naturally occurring beta-amino acid (3-aminopropionic acid); building block for carnosine synthesis; serves as a precursor for more complex peptide-based cosmetic actives; highly water-soluble
Regulatory Flags
Frequently Asked Questions
Is Beta-Alanine safe in cosmetics?
Very low toxicity profile; naturally occurring amino acid; may cause transient paresthesia (tingling) at high oral doses but this is not relevant at typical cosmetic use levels. A naturally occurring beta-amino acid (3-aminopropionic acid); building block for carnosine synthesis; serves as a precursor for more complex peptide-based cosmetic actives; highly water-soluble The EU classifies Beta-Alanine as "permitted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.
Is Beta-Alanine allowed in the EU?
Beta-Alanine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Beta-Alanine do in cosmetics?
Beta-Alanine functions as: Skin conditioning, hair conditioning, buffering. It is classified as a cosmetic ingredient in our database. CAS number: 107-95-9.
What is the Margin of Safety for Beta-Alanine?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Beta-Alanine?
The NOAEL (No Observed Adverse Effect Level) for Beta-Alanine is 3000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 3 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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