Is Beta-Alanine safe in cosmetics?
Beta-Alanine has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Beta-Alanine
Also known as: EINECS 203-536-5, FEMA No. 3252, 3-Aminopropionsaeure, beta-Aminopropionsaeure, UNII-11P2JDE17B (+15 more)
INCI: BETA-ALANINE
Beta-Alanine (CAS 107-95-9) is a cosmetic cosmetic ingredient functioning as Skin conditioning, hair conditioning, buffering. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 107-95-9 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning, hair conditioning, buffering
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3-aminopropanoic acid
InChIKey
UCMIRNVEIXFBKS-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed - also holds GRAS (Generally Recognized As Safe) status for food use; no cosmetic-specific restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Beta-Alanine.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Beta-Alanine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 3000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Beta-Alanine across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Regulatory (3)
JECFA Number
1418
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3-AMINOPROPANOIC ACID | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/98 | FAS 54-JECFA 63/435
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
beta-ALANINE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/98 | FAS 54-JECFA 63/435
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Humectant
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Beta-Alanine.
Regulatory Flags
natural-origin
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Beta-Alanine by CAS number or substance name.
Studies
2
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
3000 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
Known Synonyms
EINECS 203-536-5
FEMA No. 3252
3-Aminopropionsaeure
beta-Aminopropionsaeure
UNII-11P2JDE17B
3-Amino-Propanoate
3-Amino-Propanoic acid
3-Aminopropionate
H-beta-Ala-OH
Omega-Aminopropionate
b-Aminopropanoate
b-Aminopropanoic acid
b-Aminopropionate
b-Aminopropionic acid
bAla
beta Alanine
beta-Aminopropanoate
beta-Aminopropanoic acid
beta-Aminopropionate
beta-aminopropionic acid
Chemical Function
Humectant
Flavouring and nutrient
Regulatory Lists
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
BETA-ALANINE
ChEMBL ID
CHEMBL297569
Frequently Asked Questions
Is Beta-Alanine allowed in the EU?
Beta-Alanine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Beta-Alanine do in cosmetics?
Beta-Alanine functions as: Skin conditioning, hair conditioning, buffering. It is classified as a cosmetic ingredient in our database. CAS number: 107-95-9.
What is the NOAEL for Beta-Alanine?
The NOAEL (No Observed Adverse Effect Level) for Beta-Alanine is 3000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Is Beta-Alanine used outside cosmetics?
Beta-Alanine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Beta-Alanine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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