Is Methoxymethylbutanol safe in cosmetics?
Methoxymethylbutanol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Methoxymethylbutanol
Also known as: 1-Butanol, 3-methoxy-3-methyl-, EINECS 260-252-4, 3-Methoxy-3-methyl-1-butanol, 3-Methyl-3-methoxybutanol, UNII-366754K2K1
INCI: METHOXYMETHYLBUTANOL
Methoxymethylbutanol (CAS 56539-66-3) is a cosmetic cosmetic ingredient functioning as Solvent, fragrance functional (excipient for perfume oils). NOAEL 60 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 56539-66-3 →
Auto-generated CPSR Part A draft with source citations
Function
Solvent, fragrance functional (excipient for perfume oils)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3-methoxy-3-methylbutan-1-ol
InChIKey
MFKRHJVUCZRDTF-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed; no specific prohibition
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Methoxymethylbutanol.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Methoxymethylbutanol across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Solvent
Regulatory List Membership (2)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
Expert Verdict
Expert safety assessment and concern-level summary for Methoxymethylbutanol.
Regulatory Flags
fragrance-component
epa_safer_alternative
ifra_fragrance
Known Synonyms
1-Butanol, 3-methoxy-3-methyl-
EINECS 260-252-4
3-Methoxy-3-methyl-1-butanol
3-Methyl-3-methoxybutanol
UNII-366754K2K1
Chemical Function
Solvent
Fragrance
Regulatory Lists
IFRA Transparency
air; Cleaning products and household care; detected; emissions
air; detected; emissions; Personal care
air; Cleaning products and household care - air freshener; detected; emissions
SCIL (9/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3188023
Frequently Asked Questions
Is Methoxymethylbutanol allowed in the EU?
Methoxymethylbutanol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methoxymethylbutanol do in cosmetics?
Methoxymethylbutanol functions as: Solvent, fragrance functional (excipient for perfume oils). It is classified as a cosmetic ingredient in our database. CAS number: 56539-66-3.
Is Methoxymethylbutanol used outside cosmetics?
Methoxymethylbutanol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Methoxymethylbutanol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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