Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Methoxymethylbutanol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 2 2101 | 9155 | rat | inhalation | REACH |
| NOAEL | 250 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 60 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
EWG SkinDeep score of 1 (lowest concern). Completely miscible with water; boiling point 173-175 °C; density 0.926 g/mL at 20 °C; adding 10% water renders flashpoint unmeasurable (fire safety advantage)
Regulatory Flags
Frequently Asked Questions
Is Methoxymethylbutanol safe in cosmetics?
EWG SkinDeep score of 1 (lowest concern). Completely miscible with water; boiling point 173-175 °C; density 0.926 g/mL at 20 °C; adding 10% water renders flashpoint unmeasurable (fire safety advantage) The EU classifies Methoxymethylbutanol as "permitted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.
Is Methoxymethylbutanol allowed in the EU?
Methoxymethylbutanol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methoxymethylbutanol do in cosmetics?
Methoxymethylbutanol functions as: Solvent, fragrance functional (excipient for perfume oils). It is classified as a cosmetic ingredient in our database. CAS number: 56539-66-3.
What is the Margin of Safety for Methoxymethylbutanol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Methoxymethylbutanol?
The NOAEL (No Observed Adverse Effect Level) for Methoxymethylbutanol is 2 2101 based on a inhalation study via 9155 route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
Check Methoxymethylbutanol compliance across multiple jurisdictions:
Related Ingredients
Is Methoxymethylbutanol in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Methoxymethylbutanol in your formulation.