Methyl Isovalerate

INCI: METHYL ISOVALERATE (METHYL 3-METHYLBUTANOATE)

CAS Number
556-24-1
Function
Fragrance, flavoring agent
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Allowed; FEMA GRAS as a flavoring substance

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Low concern; may cause mild skin irritation at high concentrations; generally recognized as safe at typical fragrance/flavor levels. Fruity ester with an apple/rum-like aroma; volatile; commonly used in flavor and fragrance compositions at low concentrations

⚠️
Concern Level: Moderate

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Methyl Isovalerate safe in cosmetics?

Low concern; may cause mild skin irritation at high concentrations; generally recognized as safe at typical fragrance/flavor levels. Fruity ester with an apple/rum-like aroma; volatile; commonly used in flavor and fragrance compositions at low concentrations The EU classifies Methyl Isovalerate as "permitted". Safety rating: MODERATE.

Is Methyl Isovalerate allowed in the EU?

Methyl Isovalerate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methyl Isovalerate do in cosmetics?

Methyl Isovalerate functions as: Fragrance, flavoring agent. It is classified as a cosmetic ingredient in our database. CAS number: 556-24-1.

What is the Margin of Safety for Methyl Isovalerate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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