Methylenedioxybenzoyl Ethyl PABA

INCI: METHYLENEDIOXYBENZOYL ETHYL PABA

CAS Number
333432-71-6
Function
UV absorber / UV filter
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not listed among the 16 FDA-approved OTC sunscreen active ingredients in the US; would require an NDA/new monograph pathway for use as an active UV filter

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Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

PABA (para-aminobenzoic acid) derivatives have historically raised concerns about photoallergy and phototoxicity; however, newer PABA derivatives are generally considered to have improved safety profiles. A structural hybrid combining a methylenedioxybenzamide moiety with ethyl PABA, designed to provide broadened UV absorption while reducing the sensitization issues associated with older PABA sunscreens

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Concern Level: High

Frequently Asked Questions

Is Methylenedioxybenzoyl Ethyl PABA safe in cosmetics?

PABA (para-aminobenzoic acid) derivatives have historically raised concerns about photoallergy and phototoxicity; however, newer PABA derivatives are generally considered to have improved safety profiles. A structural hybrid combining a methylenedioxybenzamide moiety with ethyl PABA, designed to provide broadened UV absorption while reducing the sensitization issues associated with older PABA sunscreens The EU classifies Methylenedioxybenzoyl Ethyl PABA as "permitted". Safety rating: MODERATE.

Is Methylenedioxybenzoyl Ethyl PABA allowed in the EU?

Methylenedioxybenzoyl Ethyl PABA EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methylenedioxybenzoyl Ethyl PABA do in cosmetics?

Methylenedioxybenzoyl Ethyl PABA functions as: UV absorber / UV filter. It is classified as a cosmetic ingredient in our database. CAS number: 333432-71-6.

What is the Margin of Safety for Methylenedioxybenzoyl Ethyl PABA?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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