Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Trimethoxycaprylylsilane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 175 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Methanol release during hydrolysis/condensation on particle surfaces — relevant at manufacturing stage, not in finished product; standard silicone ingredient considerations
Frequently Asked Questions
Is Trimethoxycaprylylsilane safe in cosmetics?
Methanol release during hydrolysis/condensation on particle surfaces — relevant at manufacturing stage, not in finished product; standard silicone ingredient considerations The EU classifies Trimethoxycaprylylsilane as "permitted". Safety rating: EXCELLENT. 2 toxicological study endpoint(s) are available in our database.
Is Trimethoxycaprylylsilane allowed in the EU?
Trimethoxycaprylylsilane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Trimethoxycaprylylsilane do in cosmetics?
Trimethoxycaprylylsilane functions as: Surface modifier, binder, skin conditioning (hydrophobic pigment/UV filter surface treatment). It is classified as a cosmetic ingredient in our database. CAS number: 3069-40-7.
What is the Margin of Safety for Trimethoxycaprylylsilane?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Trimethoxycaprylylsilane?
The NOAEL (No Observed Adverse Effect Level) for Trimethoxycaprylylsilane is 175 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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