Excellent Cosmetic Ingredient NOAEL Data

Tris-Biphenyl Triazine

INCI: TRIS-BIPHENYL TRIAZINE / TRIS-BIPHENYL TRIAZINE (NANO)

CAS Number
31274-51-8
Function
UV Filter – most efficient UVB + UVA2 (290–340 nm) filter known; highly photostable
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
EU Max Conc. 10%
🇺🇸 US Status permitted
US Notes NOT approved – not on FDA OTC sunscreen monograph; not permitted in US market

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Tris-Biphenyl Triazine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1000 mg/kg bw/day dermal rat dermal REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH

Expert Verdict

US market exclusion – cannot be used in FDA-regulated sunscreens; nano form requires "nano" labeling in EU; inhalation risk prohibits spray application

⚠️
Concern Level: None

Regulatory Flags

eu_cosing_listed

Frequently Asked Questions

Is Tris-Biphenyl Triazine safe in cosmetics?

US market exclusion – cannot be used in FDA-regulated sunscreens; nano form requires "nano" labeling in EU; inhalation risk prohibits spray application The EU classifies Tris-Biphenyl Triazine as "permitted". Safety rating: EXCELLENT. 2 toxicological study endpoint(s) are available in our database.

Is Tris-Biphenyl Triazine allowed in the EU?

Tris-Biphenyl Triazine EU regulatory status: permitted. Maximum allowed concentration: 10%. This is based on EU Regulation 1223/2009 and its amendments.

What does Tris-Biphenyl Triazine do in cosmetics?

Tris-Biphenyl Triazine functions as: UV Filter – most efficient UVB + UVA2 (290–340 nm) filter known; highly photostable. It is classified as a cosmetic ingredient in our database. CAS number: 31274-51-8.

What is the Margin of Safety for Tris-Biphenyl Triazine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Tris-Biphenyl Triazine?

The NOAEL (No Observed Adverse Effect Level) for Tris-Biphenyl Triazine is 1000 mg/kg bw/day based on a dermal study via dermal route in rat. A total of 2 study endpoints are available. Source: REACH.

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